Well-defined hybrid magnetic nanoparticles by self-assembly

PMSE 70

Lyudmila M. Bronstein, lybronst@indiana.edu1, Xinlei Huang, xinhuang@indiana.edu1, Jason C. Dyke, jcdyke@indiana.edu1, Abrin Lee Schmucker, aschmuck@indiana.edu1, Chris Dufort1, Eleonora V. Shtykova2, Dmitri I. Svergun, svergun@embl-hamburg.de3, and Bogdan Dragnea, dragnea@indiana.edu1. (1) Department of Chemistry, Indiana University, 800 E Kirkwood Av, Bloomington, IN 47405, (2) Institute of Crystallography, 59 Leninsky Pr., 117333, Moscow, Russia, (3) Hamburg Outstation, European Molecular Biology Laboratory, Notketstr. 85, Hamburg, 22603, Germany
Self-assembly processes can be successfully used to encapsulate hydrophobic magnetic nanoparticles (NPs) using polymeric molecules. The NPs are obtained by thermal decomposition of iron oleates in the long chain saturated hydrocarbon solutions. As the first step of functionalization we suggest encapsulation of NPs by PEGylated phospholipids. The resultant NPs are water soluble and biocompatible. When they contain carboxy groups in their exterior, they can induce self-assembly of Brome Mosaic virus proteins leading to magnetic virus-like particles (VLPs). The structure of the PEGylated phospholipid shell was found to depend on the NP size. This structure, in turn, influences the VLP formation. The hierarchical self-assembly affords well-defined VLPs, whose magnetic properties make them prospective candidates for specific MRI contrast agents with enhanced properties.
 

Synthesis and Self-Assembly Approaches to Polymer-Inorganic Hybrid Nanoparticles
8:30 AM-12:00 PM, Monday, April 7, 2008 Hilton New Orleans Riverside -- Grand Salon 24, Oral

Division of Polymeric Materials: Science & Engineering

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008