CHED 252 |
| Capillary electrophoresis (CE) was used to achieve enantiomeric separation of the 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (2-APA NSAIDs) naproxen, flurbiprofen, ketoprofen, and ibuprofen. Heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-β-CD) and the macrocyclic antibiotic vancomycin were used as running buffer chiral selectors (CS). Studies on the effects of buffer pH and CS type and concentration yielded significant differences in enantiomeric resolution under various conditions. It was determined that higher CS concentrations and lower pH buffers lead to greater resolution, along with a significant increase in retention time of the samples. Enantiomeric resolution was achieved for all individually tested racemic NSAIDs for both CS. |
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Undergraduate Research Poster Session: Analytical Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |