CARBTuesday, August 21, 2007

1:25 PM-4:45 PM BCEC -- 208, Oral
RNA Interference Based Therapeutics
Organizer:Muthiah Manoharan
Presiding:Alan M. Gewirtz
1:25 PMIntroductory Remarks
1:30 PMDelivering RNAi Therapeutics
John Maraganore
2:05 PMMicroRNAs as therapeutic targets
C. Frank Bennett
2:40 PMDelivery of siRNA using stable nucleic acid lipid particles (SNALP)
Ian MacLachlan
3:15 PMIntermission
3:25 PMA polymer-based nanoparticle delivery system for targeted, systemic delivery of siRNA
Jeremy D. Heidel
4:00 PM2'-O-ALE (acetal levulinylester) and 2'-O-ester groups for 2'-hydroxyl protection in the solid-phase synthesis and delivery of siRNA
Jeremy G. Lackey, Gallant Pascal, Mathew Hassler, Masad J. Damha
4:15 PMLipophilic conjugates for the in vivo delivery of siRNA
Muthusamy Jayaraman, K. Narayanannair Jayaprakash, Gang Wang, Rajendra K. Pandey, Tomoko Nakayama, Tim Racie, Tracy Zimmermann, Martin A. Maier, Victor Kotelianski, Kallanthottathil G. Rajeev, Muthiah Manoharan
4:30 PMMetal-ion chelated siRNA used to study distribution and uptake of siRNA
Yupeng Fan, Rajendra K. Pandey, Martin A. Maier, Kallanthottathil G. Rajeev, Dinah WY. Sah, Muthiah Manoharan

Previous Session -- RNA Interference Based Therapeutics

Symposium Grid -- Division of Carbohydrate Chemistry -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007