| MEDI | Monday, August 20, 2007 | ||
8:00 PM-10:00 PM BCEC -- Exhibit Hall - B2, Sci-Mix | |||
Sci-Mix | |||
| Presiding: | James R. McCarthy | ||
| 29 | 3-(Amino)alkoxy indoles: Novel class of centrally acting anti-obesity agents Ramakrishna V. S. Nirogi, Anand V Daulatabad, Narendra Varma Gaddiraju, Parandhama Gudla, Mallesh Junnuri, Srinivasulu Kota, Rama Sastry Kambhampati, Anil K. Shinde | ||
| 63 | Nε-methanesulfonyl-lysine as a nonhydrolyzable functional surrogate for Nε-acetyl-lysine Nuttara Jamonnak, David G. Fatkins, Lanlan Wei, Weiping Zheng | ||
| 66 | Analogs of orotidine monophosphate (OMP): Their effect on the activity of OMP decarboxylase Srinath Thirumalairajan, Stephen L. Bearne | ||
| 67 | Assessing the role of tyrosine 190 in the catalytic mechanism of hamster N-acetyltransferase 2 by site-directed mutagenesis, pre-steady state and steady state kinetic studies Xin Zhou, Li Liu, Patrick E. Hanna, Carston R. Wagner | ||
| 298 | Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series Christina Ng Di Marco, Robert M. DiPardo, Ronald K. Chang, Kathy L. Murphy, Richard W. Ransom, Duane Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas Pettibone, Mark G. Bock, Scott D. Kuduk | ||
| 277 | Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites Birgitte H. Kaae, Kasper Harpsøe, Alberto Contreras Sanz, Darryl S. Pickering, Per Sauerberg, Rasmus P. Clausen, Jette S. Kastrup, Tommy Liljefors, Ulf Madsen | ||
| 358 | Design and SAR of thiazole-based inhibitors for the ABL-T315I enzyme Chun P. Chow, Jianguo Cao, Elena Dneprovskaia, Richard Fine, Ehab Hanna, John Hood, Linda Hwang, Xinshan Kang, Boris Klebansky, Dan Lohse, Chi-Ching Mak, Andrew McPherson, Glenn Noronha, Moorthy S. S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng, Hong Zhu | ||
| 362 | Design and synthesis of luminescent terbium(III) chelates: Application for kinase assay development George Guoliang Yi, Sukanta Bhattacharyya, Annegret Boge, Francisco Ramirez, J. Richard Sportsman | ||
| 64 | Design, synthesis and bioactivity of novel inhibitors of E. coli Aspartate Transcarbamoylase Joby Eldo, Sabrina Heng, Evan R. Kantrowitz | ||
| 70 | Design, synthesis and chemical reactivity of 1,4-naphtoquinone derivatives as cysteine protease irreversible inhibitors Claudia Valente, Rui Moreira, Rita C. Guedes, Jim Iley, Mohammed Jaffar, Kenneth T. Douglas | ||
| 288 | Design, synthesis and in vivo results of chemically-modified antisense oligonucleotides targeting microRNA-122 Garth A. Kinberger, Stephanie Propp, Scott Davis, Susan Freier, Christine Esau, Eric E. Swayze, C. Frank Bennett, Balkrishen Bhat | ||
| 354 | Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogs as antitumor CDK inhibitors Ronghui Lin, Peter Connolly, George Chiu, Yang Yu, Shengjian Li, Stuart Emanuel, Lee Greenberger | ||
| 68 | Development of C2-symmetric, active site-directed inhibitors for Cystathionine beta-Synthase Christopher D. McCune, Weijun Shen, Woo Jin Chung, David B. Berkowitz | ||
| 409 | Discovery and optimization of a small molecule series that induces a novel isotropic growth phenotype in C. Albicans Scott Collibee, Thomas Lila, Bradley Morgan, Penelope Chua, Matthew Hamilton, Takashi Nakai, Daniel Pierce, David J. Morgans Jr., Charles Vacin, David Clarke | ||
| 55 | Discovery and optimization of arysulfonamide as a novel class of 11beta-HSD1 inhibitors Daqing Sun, Michael DeGraffenreid, Xiao He, Juan Jaen, Jay P. Powers, Xuelei Yan, Yongmei Di, Hua Tu, Stefania Ursu, Ji Ma, Shichang Miao, Liang Tang, Qiuping Ye, Athena Sudom, Zhulun Wang | ||
| 48 | Discovery and synthesis of nipecotic amide as novel, potent and selective 11ß-HSD-1 inhibitors Jincong Zhuo, Meizhong Xu, Colin Zhang, Dingquan Qian, Yanlong Li, Reid Huber, Maryanne Covington, Cindy Marando, Brian Metcalf, Wenqing Yao | ||
| 400 | Discovery of new generation of photodynamic therapeutics by an efficient combinatorial synthesis using porphyrin platform Mikki Vinodu, Diana Samaroo, Xin Chen, Charles Michael Drain | ||
| 365 | Discovery of ß-sulfonamide piperidine hydroxamates as potent and selective HER-2 sheddase inhibitors David M. Burns, Chunhong He, Yanlong Li, Peggy Scherle, Maryanne Covington, Max Pan, Richard Wynn, Sharon Turner, Jordan S. Fridman, Steve Friedman, Brian Metcalf, Wenqing Yao | ||
| 69 | Discrimination of carbonic anhydrase isozymes by the excited-state lifetimes of polymerized liposome incorporated lanthanide ions Adekunle Elegbede, Manas Haldar, Sumathra Manokaran, Sanku Mallik, D. K. Srivastava | ||
| 106 | Impact of secondary structure of agonists of Toll-like receptor 9 on immune stimulatory activity Dong Yu, Mallikarjuna R Putta, Lakshmi Bhagat, Daqing Wang, Meiru Dai, Jimmy X. Tang, Ekambar R. Kandimalla, Sudhir Agrawal | ||
| 58 | Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide 1 He Meng, Krishna Kumar | ||
| 302 | Inhibitors of NF-Kappa B derived from thalidomide Bulbul Pandit, Esperanza Carcache de Blanco, Zhigen Hu, Pui Kai Li | ||
| 323 | Mechanism of action of bioactive tamoxifen conjugates Emily L. Rickert, Xinghua Long, Anton C. Peterson, Joseph P. Trebley, Melinda M. Morrell, Ken P. Nephew, Ross Weatherman | ||
| 317 | Microwave-expediated synthesis of 5-aminosubstituted camptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1Ą Blair T Lapointe, Joelle Torregrossa, Kristen Bailey, Christopher Barone, Ryan T Coccia, Catherine Y Cote, Conor P Davern, Theresa A Dunstan, Benjamin J Durant, Nisal U Gajadeera, David A Garcia, Daniel I Gotleib, Andrea I Lebed, Emily A Lewis, Steven L Mathieu, Melissa L McNeel, Stephanie E Muser, Catherine M Norwood, Samantha M Rupert, Timothy F Siclari, Jason M Silverberg, Zachary P Thompson, Danielle Falcone, Glenn J. Bubley, Graham Jones | ||
| 73 | Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase James M. Hogan, Sylvine Deprele, Boris A. Kashemirov, BL Barnett, Artem Evdokimov, Jim Dunford, R. Graham G. Russell, Frank H. Ebetino, Charles E. McKenna | ||
| 122 | Multimodal nanoagent for the diagnosis and treatment of atherosclerosis Jason R. McCarthy, Ethan Korngold, Farouc Jaffer, Ralph Weissleder | ||
| 367 | Nanomedicinal chemistry: Preparation of novel tyrosine kinase inhibitor-targeted linkers for nanoparticle targeting Robert N. Hanson, Kristin Bailey, Marah Elston, J. Adam Hendricks | ||
| 318 | Novel duocarmycin-analog based antibody drug conjugate for targeted cancer therapy Vincent Guerlavais, Qian Zhang, Kilian Horgan, Sharon Boyd, Bilal Sufi, Liang Chen, Lynae Green, David Passmore, Janette Sung, Rangan Vangipuram, Lourdes Thevanayagam, Mohan Srinivasan, Mary Do, Rory Dai, Eilene Kwok, Colin Chong, Carol Soderberg, Chin Pan, Mary Huber, Peter Sattari, Chetana Rao, Shrikant Deshpande, Pina Cardarelli, David J. King, Sanjeev Gangwar | ||
| 352 | One-pot synthesis of dihydro-imidazo and imidazo-phenanthridinium DNA intercalating platforms as promising anticancer agents Leroy Cronin, Alexis D. C. Parenty | ||
| 104 | Peptide nucleic acid (PNA) FRET agents for imaging gene expression Bereket Y. Oquare, Huafeng Fang, John-Stephen Taylor | ||
| 308 | PMSA antibody-toxin conjugates as antiprostatic agents Danielle Falcone, Glenn J. Bubley, Graham Jones | ||
| 45 | Small-molecule Y2 receptor antagonists: Identification of a novel and potent series using pharmacophore-based virtual screening Mark Seierstad, Pascal Bonaventure, Lisa Dvorak, Brian Lord, Kirsten L. Miller, S. Timothy Motley, Diane H. Nepomuceno, Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Chandra Shah, Devin M. Swanson, Victoria D. Wong, Frank U. Axe, Timothy W. Lovenberg, Nicholas I. Carruthers | ||
| 202 | Structural dynamics of the cooperative binding of organic molecules in the human Cytochrome P450 3A4 (CYP3A4) Dan Fishelovitch, Carina Hazan, Sason Shaik, Haim Wolfson, Ruth Nussinov | ||
| 96 | Synthesis and anti-HIV activities of fatty acyl derivatives of 2',3'-dideoxy-3'-thiacytidine Hitesh Kumar Agarwal, Michael Hanley, Gustavo F. Doncel, Keykavous Parang | ||
| 36 | Synthesis and SAR of derivatives from 2, 3-dihydro-1H-spiro [isoquinoline-4, 4'-piperidine] as MC4R agonists for the treatment of obesity Jian Liu, Tianying Jian, Iyassu K. Sebhat, Rui Tang, David H. Weinberg, Tanya MacNeil, Angeles Cabello, Airu S. Chen, Howard Y. Chen, Cherrie A. Shepherd, Alison Strack, R. Miller, Ralph Stearns, Zhesheng Chen, Tom Holt, Tung M. Fong, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 47 | Synthesis and SAR of thiophene acid-mimetics as PTP1B inhibitors Eva Binnun, Zhao-Kui Wan, Bruce Follows, Steven J. Kirincich, Douglas Wilson, Wei-Xin Xu, Diane Joseph-McCarthy, Junjun Wu, Michael J. Smith, Yanling Zhang, May Tam, Dave Erbe, Steve Tam, Eddine Saiah, Jinbo Lee | ||
| 31 | Synthesis of (-)-Δ9-tetrahydrocannabinol and (-)-Δ9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs Spyros P. Nikas, Ganesh A. Thakur, Damon Parish, Shakiru O. Alapafuja, Marilyn A Huestis, Alexandros Makriyannis | ||
| 332 | Synthesis of 17-alpha-substituted arylvinyl estradiols and evaluation as ligands for the estrogen receptor ligand binding domain (ER-LBD) Robert N. Hanson, Sandra Olmsted, Pakamas Tongcharoensirikul, Emmett McCaskill, David C. Labaree, Richard B. Hochberg | ||
| 110 | Synthesis of a reactive linker for the construction of antibody-drug hybrid molecules Joshua D. Thomas, Thomas Hofer, Christoph Rader, Terrence R. Burke Jr. | ||
| 57 | Synthesis, SAR and evaluation of C-aryl glucosides as sodium-glucose cotransporter inhibitors for the treatment of type 2 diabetes Wei Meng, William N. Washburn, Bruce A. Ellsworth, Ravindar N. Girotra, Peggy J. McCann, Prashant P. Deshpande, Annie J. Pullockaran, Manorama Patel, Philip M. Sher, Gang Wu, Scott A. Biller, Deborah L. Hagan, Songping Han, Ashish Khanna, Joseph R. Taylor, Li Xin, John R. Wetterau, Jean M. Whaley | ||
| 350 | Targeting cancer cells with boronated cyclic peptides for BNCT Erin J. Ziolkowski, Katrina A. Jolliffe, Louis M. Rendina | ||
| 40 | Tetrahydro carbazoles: Novel, potent and selective 5-HT6 receptor antagonists Rama Sastry Kambhampati, Jagadish B. Konda, Prabhakar Kothmirkar, Trinath R. Bandyala, Sivasekhar NK. Yarra, Sobhanadri Arepalli, Anil K. Shinde, Ramakrishna V. S. Nirogi | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007