COMPSunday, August 19, 2007

1:00 PM-5:05 PM BCEC -- 161, Oral
Drug Discovery
Docking
Organizer:Irache Visiers
Presiding:Dominic Ryan
1:00 PMIntroductory Remarks
1:10 PMA new implicit solvent model for protein-ligand docking
Angel R. Ortiz
1:30 PMExplicit and implicit solvation binding free energies of FKBP-12
Michael R. Shirts, Guha Jayachandran, Christopher D. Snow, Vijay S. Pande, Richard A. Friesner
1:50 PMAll-atom semiempirical LocalSCF quantum-mechanical protein-ligand docking
Victor M. Anisimov, Vladislav L. Bugaenko
2:10 PMImproving the accuracy of MM-GBSA binding energy predictions through parameter optimization
B. Woody Sherman, Jianxin Duan, Matthew P. Repasky
2:30 PMUsing diverse computational approaches to understand protein/ligand binding affinities in structure-based drug design: A cross-docking study
Johannes H. Voigt, Carl Elkin, Jose S. Duca
2:50 PMIntermission
3:05 PMTAE Augmented scoring functions: Two approaches, atom and surface based
M. Dominic Ryan, Theresa Hepburn, N. Sukumar, Sourav Das, Curt M. Breneman
3:25 PMDocking ligands into challenging targets using single interactions and an appropriate metal description
Carsten Detering, Christian Lemmen, Markus Lilienthal, Marcus Gastreich
3:45 PMDevelopment of customized scoring function for the prediction of binding affinities of Aurora Kinase inhibitors
Shashidhar N Rao, B. Woody Sherman, Ramy Farid
4:05 PMKnowledge-based docking for kinases with minimal bias
Sarah Wittkopp, Julie E. Penzotti, Robert V. Stanton, Scott A. Wildman
4:25 PMSpecies selectivity of the Urotensin II receptor: Molecular Modeling study
Soo-Kyung Kim, Youyong Li, Chang Moon Park, Ravi Abrol, William A. Goddard III
4:45 PMStudy of antimalarial activity of pyrimethamin and flavonoïds by molecular docking
Abderrahmane Bensegueni, Abdelouahab Chikhi, Mustapha Bencharif

Drug Discovery -- Next Session

Symposium Grid -- Division of Computers in Chemistry -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007