BIOTWednesday, August 22, 2007

5:30 PM-7:30 PM BCEC -- Exhibit Hall - B2, Poster
Poster Session
Downstream Processing
Organizers:Yi Tang
S. Ozturk
Shyamsundar Subramanian
Critical Parameters for Efficient Tangential Flow Filter Regeneration
E Mahajan, J Liao, D Ege, D Abraham, D Wohlpart
Simulation of an industrial ion exchange step: The use of simulation for robustness analysis
Thomas B. Hansen, Lars Sejergaard, Ernst Hansen, Steffen Kidal
Simulation of an industrial ion exchange step: The use of simulation to yield a constant output with a variable input to a process step
Steffen Kidal, Ernst Hansen, Lars Sejergaard, Thomas B. Hansen
Paper Withdrawn
Characterization of peak broadening during size-exclusion chromatography of IgG2 antibodies
Alexis Leuras, Eugene Babcock, Tiansheng Li, Rahul Rajan
Cell culture conditioning to improve harvest performance and impurity removal
Matthew Westoby, Andy Koswara, Ryan Haverstock
Column simulations of chemically selective displacement systems
Alexander S. Freed, Christopher J. Morrison, Steven M. Cramer
Interrelating protein precipitation and hydrophobic interaction chromatography
Beckley K. Nfor, Koenraad Wiedhaup, Tangir Ahamed, Luuk A. M. van der Wielen, Gijs W. K. van Dedem, Emile J. A. X. van de Sandt, Michel H. M. Eppink, Marcel Ottens
Purification of recombinant collagen from transgenic corn seed
Cheng Zhang, Julio Baez, Charles E. Glatz
Activation of the IRF-3 transcription factor: The mechanisms of phosphorylation-induced IRF-3 dimerization and DNA binding
Anatoly I. Dragan, Victoria Hargreaves, Elena N. Makeyeva, Peter L. Privalov
Paper Withdrawn
Impact of process parameters on the performance of Normal Flow Parvovirus (NFP) filters in an antibody purification process
Jerrod Einerwold, Jeff Jorgensen, Brin Petersen, Amitava Kundu
Stability of the bZIP homo- and heterodimers and energetics of their interactions with DNA
Ralf Carrillo, Anatoly I. Dragan, Peter L. Privalov
Strategies for optimizing upstream clarification of cell culture fluids
Bala Raghunath, Benjamin Cacace, David Yavorsky
Paper Withdrawn
High throughput synthesis and screening for membrane filtration
Mingyan Zhou, James E. Kilduff, Daniel G. Anderson, Robert S. Langer, Georges Belfort
Investigation of chemically selective displacers using robotic high throughput screening, SPR, NMR and MD simulations
Christopher J. Morrison, Scott A. McCallum, Rahul Godawat, JA. Moore, Shekhar Garde, Steven M. Cramer
Platform technology for developing purification processes
Michel H. M. Eppink, Rick Schreurs II, Anke Gijsen, Bram Kamps, Kees Verhoeven
Rapid optimization of Protein A chromatography using a high-throughput format
Anna Gronberg, Frida Lindstrom, Tomas Bjorkman, Gustav Rodrigo
Streamline hydrophobic interaction chromatography resin screening for protein purification process development
Junfen Ma, Paul Jorjorian, Colleen Mason, Ronald Bates
Bench scale cleaning characterization of drug products in a fill-finish facility
Nitin Rathore, Nishant Bhasin, Parag Kolhe, Rich Law, Ahmad Abdul-Fattah, Linda Li, Wenchang Ji, Keith Murphy
Regulatory strategy for changing a chromatography resin in a licensed process by the use of a comparability protocol
Michael J. Rubino, Philip R. DeVoe
Chromatographic HTS and simulation for improved process development and optimization
Matthias Bensch, Jacob Nielsen, Janus Krarup, Thomas Budde Hansen, Steffen Kidal, Arne Stabe, Jürgen Hubbuch, Ernst Hansen, Lars Sejergaard
Paper Withdrawn
AKTA Crossflow for characterization of an ultrafiltration and diafiltration step
Carl W. Richey Jr.
Development of lab scale systems to evaluate micromixing in biological separations
Jennifer Girard, Matthew P Watson
ELISA based selection of elution buffer for IgG-affinity chromatography
Rajaramesh Varakala, Robert R. Beitle, Kevin Clark, Tom W Smith
Enantioselective hydrolysis of epoxides in organic solvents by Beauveria bassiana
Emmanuel G. Ankudey, Tonya L. Peeples
Risk mitigation and optimization strategies for viral filtration
Lisa Flansburg, Renyo Forng, Steven Lee, Abhinav A Shukla
Robust microscale method for yeast cell disruption in the purification of intracellular proteins
Marc D. Wenger, Peter DePhillips, Daniel G. Bracewell
Anomalous peak splitting of a human IgG2 mAb on HPLCSEC caused by charge variants
Joseph Martin, Michael Dupuis, Joan Kwong, Gregory Waszak
Buffer distribution capacity analysis at the pilot scale
Amy Caparoni, Jason B. Fletcher, Jack Sinclair
Characterization of a new IgG binder adsorbent
Patrik Adielsson, Stefan Eriksson, Faramarz Alamravesh, Hanna Wlad, Johan Färenmark
Characterization of cation exchange adsorbents for monoclonal antibody purification
Daniel Roth, Chris Daniels, Brian To
Coimmobilization of pyranose 2-oxidase, laccase, and catalase on solid supports for enhanced production of 2-keto-aldoses
Roland Ludwig, Prakit Sukyai, Tonci Resic, Dietmar Haltrich
Development of a high throughput purification method for analysis of cell culture samples
Sarah Koob, Nadine Barron, Judy H. Chou, Martin Sinacore
Development of a high-capacity downstream process for an NS0-derived human IgG2 based on 11-12 day fed batch fermentations with defined feed media
Gregory Waszak, Erwin Yu, Michael Dupuis, Joseph Martin
Development of Biacore application for influenza virus titer determination
Camilla Estmer Nilsson, Mia Bängtsson, Anita Larsson, Raf Lemmens
Monte-Carlo simulations of dye-labeled proteins diffusing in nanopores
Johannes Hohlbein, Martin Steinhart, Erik Hinze, Cordelia Schiene-Fischer, Christian G. Hübner, Ulrich Gösele
ELISA for Quantifying trace amount of an alkaline stabilized protein A in high concentration of mAbs
Tomas Bjorkman
High resolution anion exchange chromatography purification of oligonucleotides
J. Kevin O'Donnell, Eric Gershenow, Bruce Kempf, Shigeru Nakatani
Enhancing the thermostability of β-mannanase by addition of sugars, polylols and their combinations
Weina Wu, Zhaohui Liu, Wei Qi, Zhimin He
Evaluation of protein A chromatography media for capture of monoclonal antibodies
Bjarne R. Nielsen, John S. Nielsen
Extraction of intracellular oxalate decarboxylase from the white-rot wood decay fungus Trametes versicolor
Cui Xia Zhu, Feng Hong
Impact of lot-to-lot variability of cation exchange resin on process performance
Jane Wahome, Aberash Berhe, Jeff Jorgensen, Jerrod Einerwold, Weichang Zhou, Amitava Kundu
Impact of process parameters on the performance of Normal Flow Parvovirus (NFP) filters in an antibody purification process
Jerrod Einerwold, Jeff Jorgensen, Brin Petersen, Amitava Kundu
Isolation, identification, and characterization of heavy chain clips and an expressed intron in a CHO-produced mAb
Michael Dupuis, John Finnessy, Joseph Leone, Tara Carter, Joseph Martin
Kinetics and thermodynamics of thermal inactivation and the thermostable mechanism of protective additives for beta-mannanase
Zhaohui Liu, Weina Wu, Wei Qi, Zhimin He
Libraries of multimodal chromatographic ion exchanger for the discovery of new selectivities and as a tool for HTPD
Ingela Blomqvist, Patrik Adielsson, Johan Färenmark, Jean-Luc Maloisel
Mechanisms of protein A leaching
Corazon Victa, Jayme N. Franklin, Paul J McDonald, Robert Fahrner
Novel denitrification process of electrochemical biocatalyst and its stability
Jeong Soo Cho, Jae Yeon Park, Young Tae Park, Young Je Yoo
Preparation and characterization of alcohol dehydrogenase-containing liposomes for improving its quaternary structure
Makoto Yoshimoto, Mami Sato, Katsumi Nakao
Process-specific range finding of chromatography resin lots used in the purification process of a recombinant product
Lillian Lee, Jeffrey Suchecki, Kristie Apgar, Dicky Abraham
Production of biodiesel by transesterification with new supported solid state alkali catalyst CaO/NaY
Haitang Wu, Yujie Zhou, Jianan Zhang, Jian Liu
Successful scale-up of pH elution on cation-exchange column for the purification of monoclonal antibodies
Ferhana Zaman, Judy Glynn, Natrajan Ramasubramanyan, Paul Mensah
Use of analytical ultracentrifugation with a fluorescence detector to characterize high protein concentration formulations
Zephania W Kwong, Jamie Moore, Jun Liu, Ye Shen, Qing Zhu, Tim Kamerzell, Thomas M. Laue, Steven J. Shire

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The 234th ACS National Meeting, Boston, MA, August 19-23, 2007