| TOXI | Tuesday, August 21, 2007 | ||
6:00 PM-10:00 PM BCEC -- 204 A/B, Poster | |||
Poster Session and Awards | |||
| Organizer: | Kent S. Gates | ||
| 35 | Kinetics and characterization of oxaliplatin-DNA adduct formation in naked DNA and cancer cells using accelerator mass spectrometry Sang Soo Hah, Rhoda A. Sumbad, Kenneth W Turteltaub, Paul T. Henderson | ||
| 36 | A rule-based method for comprehensive risk assessment of the mutagenic potential of drugs Catrin Hasselgren Arnby, Lars Carlsson, Claire Gavaghan, Scott Boyer | ||
| 37 | Estrogen sulfotransferase inhibition modulates estradiol in human mammary cell systems Roseanne Y. Meyer, Roberta S. King | ||
| 38 | Nitrogen mustard-induced cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to its DNA substrate Rachel L. Loeber, Melissa Goggin, Danae R. Quirk Dorr, Anthony E. Pegg, Natalia Tretyakova | ||
| 39 | A survey of RNA damage products in the SJL mouse model of inflammation Bo Pang, Jose L. McFaline, Matthew R. Sullivan, C. Eric Elmquist, Peter C. Dedon | ||
| 40 | Aldo-keto reductase 1C3 regulates prostaglandin signaling in breast cancer Michael C. Byrns, Seon Hwa Lee, Ling Duan, Ian A. Blair, Trevor M. Penning | ||
| 41 | Chemical properties of malondialdehyde nucleoside adducts and their amino acid crosslinks Joseph Szekely, Carmelo J. Rizzo, Lawrence J. Marnett | ||
| 42 | Synthesis of and mechanisms of DNA damage by 3-cyclopropyl-1,2,4-benzotriazine 1,4-dioxide Ujjal Sarkar, Kent S. Gates | ||
| 43 | Drug metabolism in 3-D perfused microreactor liver cultures Ju Liu, Walker Inman, Sharon Karakattu, Michal Bokayza, Karel Domansky, Keith Hoffmaster, Linda G. Griffith, Steve R. Tannenbaum | ||
| 44 | E. coli DNA polymerase I catalyzed incorporations of dATP and dGTP opposite N2-(7,8,9,10-tetrahydrobenzo[a]pyren-10-yl)-2'-deoxyguanosine occur by different mechanisms A. S. Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Thomas E. Spratt | ||
| 45 | Development of an in vitro model for the study of drug-induced bile acid synthesis and transport dysfunction in a 3-D tissue engineered liver microreactor culturing system J. Ricardo Llamas Vidales, Ju Liu, Jung Nyun Kim, Sharon Karackattu, Michal Bokayza, Keith Hoffmaster, Steve R. Tannenbaum, Linda G. Griffith | ||
| 46 | A synthetic nucleoside probe that discerns a DNA adduct from unmodified DNA Jiachang Gong, Shana J. Sturla | ||
| 47 | Acute toxicity (LD50) modeling utilizing fragmental QSAR, similarity analysis and reliability of prediciton Pranas Japertas, Remigijus Didziapetris, Alanas Petrauskas | ||
| 48 | An LC-ESI-MS/MS technique for quantifying polar oxidized guanine nucleotides from DNA digests Peter G. Slade, John S. Wishnok, Steven R. Tannenbaum | ||
| 49 | Analysis of 8-oxo-2`-deoxyguanosine in human bronchoalveolar dells by immunoaffinity liquid chromatography/mass spectrometry Dipti Mangal, Seon Hwa Lee, Jong Heum Park, Trevor M. Penning, Ian A Blair | ||
| 50 | Benzo[a]pyrene-7,8-dihydrodiol produces reactive oxygen species via the Aldo-Keto Reductase (AKR) pathway in A549 cells: Involvement of BP-mediated redox cycling and alteration in redox status Jong Heum Park, Kirk A. Tacka, Trevor M. Penning | ||
| 51 | Bulge migration of the malondialdehdye OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene Yazhen Wang, Sam Selch, Lawrence J. Marnett, Michael P. Stone | ||
| 52 | Bypass of dG-AAF by human polymerase ι : Molecular dynamics studies Kerry P. Donny-Clark, Lihua Wang, Robert Shapiro, Suse Broyde | ||
| 53 | Characterization of a novel glutathione adduct from arachidonic acid metabolism Kannan Rangiah, Seon Hwa Lee, Angela Y Wehr, Ian A Blair | ||
| 54 | Characterization of DNA adducts formed by3,5-dimethylaniline Liang Cui, Jimmy Flarakos, Laura J. Trudel, H. Patty Sun, Rosa G. Liberman, John S. Wishnok, Paul L. Skipper, Steven R. Tannenbaum | ||
| 55 | DNA-Binding by analogs of the left-half of azinomycin: A minimal DNA-intercalating structure Joseph Szekely, Hong Zang, Michael Shipman, Kent S. Gates | ||
| 56 | Computational analysis of the lesion recognition mechanism of formamido-pyrimidine DNA glycosylase Kun Song, Carlos De los Santos, Arthur P. Grollman, Carlos L. Simmerling | ||
| 57 | Correlation between mutation, gene expression and DNA adduct formation in human lymphoblast cells dosed with benzo[a]pyrene diol epoxide Caroline Ceailles, Wen Luo, Wenhong Fan, Lue P Zhao, Helmut Zarbl, Paul Vouros | ||
| 58 | Correlative study of heavy metal levels in rat tissues by STEM coupled EDAX elemental mapping and ICP-MS spectroscopy following chronic exposure to low levels of cadmium CdCl2 Barbara A. Wilson | ||
| 59 | Covalent crosslinking of small-molecule antielectrophiles to proteins by 4-oxo-2-nonenal Lawrence M. Sayre, Xiaochun Zhu | ||
| 60 | Defining the spectrum of protein carbonyls formed in cytochrome C by peroxidation of linoleic acid Junghyun Son, Michelle V. Williams, John S. Wishnok, Steven R. Tannenbaum, Peter C. Dedon | ||
| 61 | DNA polymerase V allows bypass of toxic guanine oxidation products in vivo William L. Neeley, Sarah Delaney, Yuriy O. Alekseyev, Daniel F. Jarosz, James C. Delaney, Graham Walker, John M. Essigmann | ||
| 62 | DNA sequence effect on the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the recognition sequence of the NarI restriction enzyme Feng Wang, C. Eric Elmquist, James S. Stover, Carmelo J. Rizzo, Michael P. Stone | ||
| 63 | Comparison between the Base Eversion of 8OG:C and G:C Arthur J. Campbell, Arthur P. Grollman, Carlos L. Simmerling | ||
| 64 | DNA-protein cross-links between guanine and lysine depend on the mechanism of oxidation Xiaoyun Xu, James G. Muller, Cynthia J. Burrows | ||
| 65 | Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: Enhanced mobility in TGT explains conformational heterogeneity, more flexible bending and greater nucleotide excision repair susceptibility Yuqin Cai, Nicholas E. Geacintov, Suse Broyde | ||
| 66 | Effect of sequence context on rate and yield of interstrand crosslinks generated by abasic sites in duplex DNA Derrick R. Seiner, Sanjay Dutta, Kent S. Gates | ||
| 67 | Enzymatic modulation of protein tyrosine phosphatase inactivation by H2O2: Phosphoryl transfer to produce peroxymonophosphate Jason LaButti, Kent S. Gates | ||
| 68 | Formation of 2′-deoxyguanosine adducts from 12(S)-hydroperoxyeicosatetraenoic acid Seon Hwa Lee, Clementina Mesaros, Ian A. Blair | ||
| 69 | Incorporation of nucleoside triphosphates opposite stereoisomeric R and S N3-(2-hydroxy-3-buten-2-yl)-2'-deoxyuridine adducts by the Sulfolobus solfataricus DNA polymerase dpo4 Wen Xu, Richard P. Hodge, R. Stephen Lloyd, Martin Egli, Michael P. Stone | ||
| 70 | Genomic approaches to understanding cellular determinants of DNA damage Shiva S. Kalinga, Rebecca C. Fry, Peter C. Dedon | ||
| 71 | Global proteomic analysis of zebrafish plasma I. Ramesh Babu, Wolfram Goessling, Leonard I. Zon, John S. Wishnok, Steven R. Tannenbaum | ||
| 72 | Glutathione concentration and the aerobic fate of the C3'-thymidinyl radical in DNA Rehana Ali Zaidi, Amanda C. Bryant-Friedrich | ||
| 73 | Human akrs display quinone reductase activity with pah o-quinones Carol A. Shultz, Amy M. Quinn, Trevor M. Penning | ||
| 74 | Identification of covalent DNA adducts in vitro from bioactivation of pentachlorophenol V G Vaidyanathan, Peter W. Villalta, Shana J. Sturla | ||
| 75 | Identification of nitrated proteins from iNOS-induced macrophages using biotin labeling and capture Jennifer R. Seal, John S. Wishnok, Steven R. Tannenbaum | ||
| 76 | Identification of quinol-thioether adducted proteins excreted in the urine after I.V. administration of 2-(glutathion-S-yl)HQ in Long-Evans rats Matthew T. Labenski, Ashley A. Fisher, George Tsaprailis, Terrence Monks, Serrine S. Lau | ||
| 77 | Implications for the existence of a heptasulfur linkage in natural o-benzopolysulfanes Adaickapillai Mahendran, David Aebisher, Edyta M. Brzostowska, Nahed Sawwan, Rafael Ovalle, Alexander Greer | ||
| 78 | Planar chirality due to a polysulfur ring in natural pentathiepin cytotoxins. Implications of planar chirality for enantiospecific biosynthesis and toxicity Adaickapillai Mahendran, Edyta M. Brzostowska, Martine Paulynice, Ronald Bentley, Alexander Greer | ||
| 79 | Synthesis of sulfur-substituted quinones from the oxidation of 5-methyl-4-mercapto-catechol and 5-methyl-3,4-dimercapto-catechol Adaickapillai Mahendran, David Aebisher, Alvaro Castillo, Joel F. Liebman, Alexander Greer | ||
| 80 | Generation and characterization of a nucleoside radical resulting from dissociative electron attachment Suaad Abdallah, CherylAnn Trzasko, Amanda C. Bryant-Friedrich | ||
| 81 | Independent generation of DNA radicals resulting from low-energy electrons Buthina Abdallah, Amanda C. Bryant-Friedrich | ||
| 82 | Influence of guanine oxidation potential on DNA-protein crosslinking reactions Eric D. A. Stemp, Alina Estonactoc, Amanda Madison, Julianna Scala, Carmen E Ochoa, Kathryn Schaefer, Kristina Kurbanyan | ||
| 83 | Inhibitory targets of fluoroquinolone antibiotics in the photosynthetic electron transport chain: SAR modeling analysis and in vitro binding studies Ludmilla Aristilde, Garrison Sposito | ||
| 84 | Insights into the determinants of the quantity and chemistry of sequence-selective guanine oxidation in DNA Yelena Margolin, Vladimir Shafirovich, Nicholas E. Geacintov, Peter C. Dedon | ||
| 85 | Intracellular arylamine N-acetyltransferase 1 (NAT1) is inactivated by the 4-nitroso metabolite of the tobacco smoke component, 4-aminobiphenyl Patrick E. Hanna, Li Liu, Carston R. Wagner | ||
| 86 | Irradiation of retinol in ethanol with UVA light: Formation of photodecomposition products, reactive oxygen species, and lipid peroxides Qingsu Xia, Jun Jie Yin, Shu-Hui Cherng, James P. Freeman, Hongtao Yu, Mary D. Boudreau, Wayne G. Wamer, Peter P. Fu | ||
| 87 | LC-MS identification of toxic alkaloids from fungi in the family Clavicipitaceae Monica S. Torres, Ajay P. Singh, Nicholi Vorsa, James F. White | ||
| 88 | LC-MS/MS analysis of nanoparticle-induced oxidative DNA damages Haizheng Hong, Yinsheng Wang | ||
| 89 | Mass spectrometric studies on the modification of cytochrome c by HNE Lawrence M. Sayre, Xiaoxia Tang | ||
| 90 | Mechanism of etheno adduct formation from the reaction of lipid peroxidation products with deoxyguanosine Katya V. Petrova, Ivan D. Kozekov, Donald F. Stec, Stephen T. Duncan, Carmelo J. Rizzo | ||
| 91 | Mechanistic studies on anti-tumor properties of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide analogs Venkatraman Junnotula, Kent Gates, Beatriz Soland, Adoracion Marin, Raquel Villar, Asuncion Burguete, Esther Vicente, Sivia Perez-silanes, Ignacio Aldana, Antonio Monge | ||
| 92 | Methylated-bay region and fjord-region PAH o-quinones form mono- and bis-conjugates with N-acetyl-L-cysteine and glutathione Carol A. Shultz, Dipti Mangal, Sridhar R. Gopishetty, Ronald. G Harvey, Ian A. Blair, Trevor Penning | ||
| 93 | Methylglyoxal-induced covalent modifications of proteins: Is there any correlation with diabetic complications? Yuan Gao, Yinsheng Wang | ||
| 94 | Mutagen/nonmutagen classification of diverse and structurally homogenous chemicals using calculated molecular descriptors: A hierarchical approach Denise Mills, Subhash C. Basak, Douglas M. Hawkins, Brian D. Gute | ||
| 95 | Use of theoretical descriptors in predicting aryl hydrocarbon (Ah) receptor binding affinity of dibenzofurans: A hierarchical QSAR approach Denise Mills, Subhash C. Basak | ||
| 96 | Novel modification of amyloid beta peptides by metal-catalyzed oxidation Tomoyuki Oe, Koichi Inoue, Clementina Mesaros, Carlos O. Garner, Bradley L. Ackermann, Ian A. Blair | ||
| 97 | Nucleotide pool as a target for nitrosative deamination during inflammation Vasileios Dendroulakis, William M. Deen, Peter C. Dedon | ||
| 98 | Oxidative DNA damage by cytotoxic N-oxides of 1-hydroxyphenazine: Toward a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine Sarmistha Sinha, Kent Gates | ||
| 99 | Potential health impacts of silver nanoparticles P V Nair Asharani, Zhiyuan Gong, Manoor Prakash Hande, Suresh Valiyaveettil | ||
| 100 | Probing the aminofluorene-induced conformational heterogeneity in a simulated translesion synthesis by 19F NMR and differential scanning calorimetry Fengting Liang, Bongsup Cho | ||
| 101 | Protein adduction by reactive lipid oxidation-derived electrophiles Simona G. Codreanu, Bing Zhang, Jeremy S. Myers, Scott M. Sobecki, Dean D. Billheimer, D. C. Liebler | ||
| 102 | Proteomic analysis of Azido-HNE adducted proteins in RKO cells Andrew Vila, Keri A. Tallman, Ned A. Porter, Daniel C. Liebler, Lawrence J. Marnett | ||
| 103 | Quantification of folate in whole blood by liquid chromatography tandem mass spectrometry Yuehua Huang, Zhiyong Lu, A. Steven Whitehead, Ian Blair | ||
| 104 | Redox regulation of protein tyrosine phosphatase 1B function by an organic peroxide: Sanjib Bhattacharyya, Kent S Gates | ||
| 105 | Role of Z-DNA in arylhydrazine carcinogenesis Vorasit Vongsutilers, Peter M. Gannett | ||
| 106 | Rule based approach for prediction of rabbit eye and skin irritation Paulius J. Jurgutis, Remigijus Didziapetris, Pranas Japertas | ||
| 107 | Sequence effects on the NarI-derived frameshift mutagenesis by 19F NMR, DSC, and CD spectroscopy Nidhi Jain, Srinivasa Rao Meneni, Bongsup Cho | ||
| 108 | Serial analysis of mutation spectra (SAMS): A new approach for the determination of mutation spectra and their sequence dependence Huafeng Fang, John-Stephen Taylor | ||
| 109 | Shoot the messenger: c-Jun-N-terminal kinase (JNK) and nuclear factor-kappaB (NF-κB) pathway components are sensors for reactive electrophiles Hansen L. Wong, Jeremy S. Myers, Simona G. Codreanu, Christopher R. Orton, Matthew E. Szapacs, Raymond W. Ganster, Dean W. Ballard, Daniel C. Liebler | ||
| 110 | Structural characterization of 1,N2-ethenodeoxyguanosine in the dodecamer 5'-CGCATethenoGGAATCC-3' Ganesh Shanmugam, Ivan D. Kozekov, F. Peter Guengerich, Carmelo J. Rizzo, Michael P. Stone | ||
| 111 | Studies on N1-inosine and N6-adenine adducts in mice after inhalation exposures to 1,3-butadiene Gunnar Boysen, Mitchell Troutman, Leonard B. Collins, James Swenberg | ||
| 112 | Synthesis and conformational characterization of the oligodeoxynucleotide duplexes modified by the model carcinogen fluoroaminobiphenyl Varsha Biyyala, Nidhi Jain, Bongsup Cho | ||
| 113 | Synthesis of alpha-methylene-deoxynucleotide triphosphates (alpha-m-dNTP) as non-cleavable substrates for polymerases Fengting Liang, Nidhi Jain, A. S. Prakasha Gowda, Thomas E. Spratt, Bongsup Cho | ||
| 114 | In vitro replication study of an intrastrand crosslink lesion G[8-5m]T and 8-oxo-2'-deoxyguanosine/thymidine glycol tandem lesion Yong Jiang, Yinsheng Wang | ||
| 115 | Systematic study of 2'-deoxyoxanosine formation during nitrosative deamination of 2'-deoxyguanosine under biologically relevant conditions Jose L. McFaline, Bo Pang, Matthew R. Sullivan, Peter C. Dedon | ||
| 116 | Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database Kun Wang, Ann Richard, Ivan Rusyn, Alexander Tropsha | ||
| 117 | Translesion DNA synthesis across pyrimido[1,2-α]purin-10(3H)-one adduct by human DNA polymerase Pol η M. Abul Kalam, Carmelo J. Rizzo, F. Peter Guengerich, Lawrence J. Marnett | ||
| 118 | Translesion synthesis past the Me-FAPy adduct in oligonucleotides by DNA polymerases Plamen P. Christov, Ivan D. Kozekov, Kyle L. Brown, Michael P. Stone, Thomas M. Harris, Carmelo J. Rizzo | ||
| 119 | Unambiguous detection and quantification of 3-(2-deoxy-β-D-erythro-pentofuranosyl)-4,6,7,8-tetrahydro-6-hydroxy-pyrimido[1,2-a]purin-10(3H)-one (6-HO-PdG) from the reaction of acrolein with calf thymus DNA Guillermo R. Alas, Ivan D. Kozekov, Constance M. Harris, Thomas M Harris, Carmelo J. Rizzo | ||
| 120 | Nitric oxide-induced deamidation retards and reverses fibril formation by an oligo(glutamine/asparagine) peptide Li Kong, Joseph E. Saavedra, kunio Nagashima, jiwen zheng, Anil Patri, Larry K. Keefer | ||
Symposium Grid -- Division of Chemical Toxicology -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007