| MEDI | Wednesday, August 22, 2007 | ||
9:00 AM-12:00 PM BCEC -- 210 B/C, Oral | |||
Abeta Production Inhibitors: Progress Toward a Clinical Test of the Amyloid Hypothesis | |||
| Official: | Lorin A. Thompson | ||
| 9:00 AM | Introductory Remarks | ||
| 9:05 AM | 241 | Session introduction: Abeta production inhibitors Charlie F. Albright | |
| 9:50 AM | 242 | Pharmacodynamics of highly potent BACE-1 inhibitors in both Pgp-deficient and normal mice Lorin A. Thompson III, Lawrence R. Marcin, Jianliang Shi, Mendi A. Higgins, Richard E. Olson, Andrew C. Good, Catherine R. Burton, Donna M. Barten, Jodi K. Muckelbauer, Jeremy H. Toyn, Kimberley A. Lentz, James E. Grace, John J Herbst, Anthony M. Marino, Jere E. Meredith, Charlie F. Albright, John E. Macor | |
| 10:25 AM | 243 | Discovery of high affinity beta-secretase inhibitors using fragment-based lead generation and structure-based design Jeffrey S. Albert | |
| 10:55 AM | 244 | BACE (Beta-Amyloid site Cleaving Enzyme; ß-Secretase) inhibitors for the treatment of Alzheimer's disease Ellen W. Baxter, Richard S. Alexander, Scott A. Ballentine, Francois P. Bischoff, Robert E. Boyd, Mirielle Braeken, Douglas E. Brenneman, Steven J. Coats, Kelly A. Conway, Andrew L. Darrow, Hans De Winter, Yifang Huang, Sergey E. Ilyin, Alfonzo D. Jordan, Ludo E. J. Kennis, Chi Luo, Marc H. Mercken, Serge M. A. Pieters, Junya Qu, Jennifer A. Piesvaux, Charles H. Reynolds, Mark J. Schulz, Malcolm K. Scott, Christopher A. Teleha, Brett A. Tounge, Allen B. Reitz | |
| 11:25 AM | 245 | Optimization of the in vivo activity of potent, Notch-sparing gamma secretase inhibitors Anthony Kreft, Boyd L. Harrison, Magid Abou-Gharbia, Jay Afragola, Asaf Alimardinov, Madelene Antane, Suzan Aschmies, Kevin Atchison, Thomas Caggiano, Michael Chlenov, Derek Cole, Thomas Comery, George Diamantidis, John Ellingboe, Kristi Fan, Cathleen Gonzalez, Diane Hauze, Molly Hoke, Yun Hu, Xinyi Huang, Donna Huryn, Uday Jain, Mei Jin, Gulnaz Khafizova, Dennis Kubrak, Kristina Kutterer, Melissa Lin, Peimin Lu, Joseph Lundquist, Ronald L. Magolda, Charles Mann, Robert Martone, Michael May, Scott Mayer, John Mehlmann, William J. Moore, Koi Morris, Aram Oganesian, Menelas Pangalos, Alex Porte, Peter Reinhart, Lynn Resnick, David R. Riddell, Jean Schmid, June Sonnenberg-Reines, Joseph Stock, Roy Sun, Erik Wagner, Zheng Wang, Kevin Woller, Zheng Xu, Margaret M Zaleska, Minsheng Zhang, Hua Zhou, J. Steven Jacobsen | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007