BIOTSunday, August 19, 2007

2:00 PM-4:20 PM BCEC -- 109B, Oral
Commercialization of Biologics: Case Studies: Post-Approval Changes & Comparability Challenges
Presiding:Steven Lee
Vikram Paradkar
2:00 PMIntroductory Remarks
2:05 PMPost approval changes for a commercial process: An historical look
Carole Heath, Hassan Madani
2:25 PMCase study: Downstream purification support of a cell culture raw material change for a licensed mAb product
Frank Maslanka
2:45 PMRituximab post approval changes and comparability assessments
Robert Kiss, Srikanth R. Chary, Steven Meier, Jason C. Goodrick, Dana C. Andersen
3:05 PMIntermission
3:15 PMDemonstrating comparability for post approval CMC changes
Reed Harris
3:35 PMComparability protocol to support a chromatography resin change
Peter J. Kramer, Rob Frankenberg, Ramadas Bhat, Parris Burd, Andrew Hetherington
3:55 PMInvestigation of an ultrafiltration yield problem for a conjugate vaccine
Shwu-Maan Lee, Bob Kruse, Amy Robinson, John Davis, Chris Donaldson
4:15 PMConcluding Remarks

Symposium Grid -- Division of Biochemical Technology -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007