| MEDI | Thursday, August 23, 2007 | ||
1:30 PM-4:50 PM BCEC -- 210A, Oral | |||
General Oral Session | |||
| Official: | James R. McCarthy | ||
| 1:30 PM | 463 | Design, synthesis and biological evaluation of ansamycin prodrugs as water-soluble Hsp90 inhibitors Steven J Moss, Barrie Wilkinson, Alexander Guiblin, Alison McElhinney, Christoph Beckmann, Lesley S Sheehan, Jean-Philippe Crochard, Andrew J Kaja, Rose M Sheridan, Mohammad Nur-E-Alam, Nigel Coates, Matthew A Gregory, Thomas Greiner, Niko Bausch, Christine J Martin, Ming Q Zhang | |
| 1:50 PM | 464 | Cu(I)Br-mediated preparation of 14C-labeled 3-pyridineacetate derivatives and synthesis of a novel 14C-labeled PDE-IV inhibitor Jonathan Z. Ho | |
| 2:10 PM | 465 | Evaluating small molecule•protein interactions in transcriptional activation Sara J Buhrlage, Anna K. Mapp | |
| 2:30 PM | 466 | Identification and development of azolidinone vinyl-fused heteroaromatic derivatives: Second generation of potent PI3Kg inhibitors, with improved oral activity in models of Rheumatoid Arthritis Thomas Ruckle | |
| 2:50 PM | 467 | Selective norepinephrine reuptake inhibitor WAY-260022 (NRI-022): Proposed therapy as a selective NRI for the treatment of neurological disorders and dysfunction Eugene J. Trybulski, Paige E. Mahaney, Lori K. Gavrin, An T. Vu, Gary Stack, Stephen Cohn, Douglas J. Jenkins, Joseph P. Sabatucci, Fei Ye, Michael B. Webb, Kimberly Sipe, Jenifer Leiter, Grace H. Johnston, Kevin Burroughs, Scott Cosmi, Liza Leventhal, Yingru Zhang, Cheryl Mugford, Brian Platt, Darlene C. Deecher | |
| 3:10 PM | 468 | Discovery of LXR Modulator WAY-252623 Jay Wrobel, Robert J. Steffan, Edward Matelan, Stephen Marc Bowen, Baihua Hu, Michael Collini, Christopher P Miller, Ray J Unwalla, Ponnal Nambi, Elaine Quinet, Liang Chen, Anita Halpern, Qiang-Yuan Liu, Dawn Savio, Eduoard Zamaratsky, Lars Kruger, Anna Wilhelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Tomas Bonn, Mathias Farnegardh | |
| 3:30 PM | 469 | Synthesis, characterization, and nuclear receptor interaction profiles of enantiomeric bile acids Bryson W. Katona, Carolyn L. Cummins, Andrew D. Ferguson, David J. Mangelsdorf, Douglas F. Covey | |
| 3:50 PM | 470 | Discovery of a novel, potent PPARa selective activator BMS-687453 Jun Li, Lawrence J. Kennedy, Yan Shi, Shiwei Tao, Xiang-Yang Ye, Stephanie Y Chen, Ravikaran Raju, Ying Wang, Andres Hernandez, Hao Zhang, Wei Wang, Pratik V. Devasthale, Sean Chen, Zhi Lai, Shung Wu, Rebecca A. Smirk, Scott A. Bolton, Denis E. Ryono, Huiping Zhang, Ngiap-Kie Lim, Bang-Chi Chen, Kenneth T Locke, Kevin M. O'Malley, Litao Zhang, Rai Ajit Srivastava, Bowman Miao, Daniel S. Meyers, Hossain Monshizadegan, Debra Search, Denise Grimm, Rongan Zhang, Thomas Harrity, Lori K. Kunselman, Michael Cap, Vinayak Hosagrahara, Lisa Zhang, Pathanjali Kadiyala, Carrie Xu, Yi-Xin Li, Jodi K. Muckelbauer, Chiehying Chang, Stanley Krystek Jr., Michael A. Blanar, Robert Zahler, Ranjan Mukherjee, Peter T. Cheng, Joseph A. Tino | |
| 4:10 PM | 471 | Development of inhibitors of menaquinone biosynthesis: A new drug target in gram-positive bacteria Michio Kurosu, Dean C Crick | |
| 4:30 PM | 472 | Discovery of novel active site-directed pharmacological chaperones to increase the cellular activity of Gaucher disease associated glucocerebrosidase variants guided by virtual screening Tingwei Mu, Yunfeng Hu, Arthur J. Olson, Jeffery W. Kelly | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007