MEDIThursday, August 23, 2007
9:00 AM-12:20 PM BCEC -- 210B, Oral
General Oral Session
Organizer:James R. McCarthy
9:00 AM453Design and synthesis of potent and efficacious 5-membered ring derivatives of gabapentin for the treatment of neuropathic pain
David C. Blakemore, Simon A. Osborne, Justin S. Bryans
9:20 AM454Discovery and SAR of orally active tri- and tetracyclic mGluR1 antagonists
Duane A. Burnett, Deen Tulshian, Stephanie Cooke, Julius Matasi, Peter Korakas, Lisa S. Silverman, Thavalakulamgara K Sasikumar, Wen-Lian Wu, Chad Bennett, Chad Knutson, William J Greenlee, A. Reggiani, A. Veltri, R. Bertorelli, S. Fredduzzi, G. Lozza, G. Tarozzo, C. Foglia, M. Grilli
9:40 AM455Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
Kassoum Nacro, Conxiang Zha, Peter R. Guzzo, R. Jason Herr, Denise Peace, Thomas D. Friedrich
10:00 AM456Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK inhibitors as antitumor agents
Ronghui Lin, Yanhua Lu, George Chiu, Shengjian Li, Yang Yu, Shenlin Huang, Peter Connolly, Xun Li, Stuart Emanuel, Steve Middleton, Mary Adams, Angel Fuentes-Pesquera, Robert Gruninger, Lee Greenberger
10:20 AM457Design and synthesis of novel second generation HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
Thomas J Tucker, Sandeep Saggar, John T Sisko, Robert M Tynebor, Peter J. Felock, Jessica A Flynn, Ming-Tain Lai, Yuexia Liang, Meiquing Liu, Mike Miller, Gregory Moyer, Vandna Munshi, Rebecca Perlow-Poehnelt, Sridhar Prasad, Rosa Sanchez, Maricel Torrent, Joseph P. Vacca, Theresa M. Williams, Bang-LIn Wan
10:40 AM458Discovery and optimization of diphenyl ether nonnucleoside inhibitors of HIV reverse transcriptase
James P. Dunn, Pete Dunten, Todd R. Elworthy, Xiaochun Han, Seth Harris, Gabrielle Heilek, Donald R. Hirschfeld, J. Heather Hogg, Ann Kaiser, Denis J. Kertesz, Woongki Kim, Klaus Klumpp, Yu Li, Taraneh Mirzadegan, Michael G. Roepel, Y. David Saito, Tania M. P. C. Silva, Steven Swallow, Zachary K. Sweeney, Jahari L. Tracy, Armando Villasenor, Harit Vora, Mark Smith, Dimitrios Stefanidis, Gouping Su, Alejandra Trejo-Martin, Amy Zhou
11:00 AM459Synthesis and anticancer activity of new migrastatin analogs
Guillaume Anquetin, Sarah L. Rawe, Paul V Murphy
11:20 AM460Design and SAR of P1-P3 ketoamide derived macrocyclic inhibitors of HCV protease
Srikanth Venkatraman, Francisco Velazquez, Wanli Wu, Melissa Blackman, Ashok Arasappan, Frank Bennett, Stephane L Bogen, Kevin Chen, Yuhua Huang, Edwin Jao, Latha Nair, Weidong Pan, Patrick Pinto, Mousumi Sannigrahi, Bancha Vibulbhan, Weiying Yang, Anil Saksena, Viyyoor Girijavallabhan, Xiao Tong, K-C. Cheng, Neng-Yang Shih, F. George Njoroge
11:40 AM461Discovery of HCV protease inhibitors: Acyclic tripeptides containing novel P-2 substituted proline
Julie Naud, Pat Forgione, Nathalie Goudreau, Christopher Lemke, Montse Llinās-Brunet
12:00 PM462Novel potent second generation HCV NS3 protease inhibitors
Kevin X Chen, Bancha Vibulbhan, Weiying Yang, Ashok Arasappan, Frank Bennett, Melissa Blackman, Stephane L Bogen, Yuhua Huang, Latha Nair, F. George Njoroge, Angela Padilla, Weidong Pan, Patrick Pinto, Mousumi Sannigrahi, Francisco Velazquez, Srikanth Venkatraman, Xiao Tong, Kuo-Chi Cheng, Neng-Yang Shih

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007