| MEDI | Wednesday, August 22, 2007 | ||
7:00 PM-9:00 PM BCEC -- Exhibit Hall - B2, Poster | |||
Poster Session | |||
| Organizer: | James R. McCarthy | ||
| 268 | Periodic classification of human immunodeficiency virus inhibitors Francisco Torrens, Gloria Castellano | ||
| 269 | 99mTc-Labeled SDF as a target-specific molecular probe for noninvasive imaging of myocardial infarction Preeti Misra, Alison D Schecter, Djamel Lebeche, Hung Ly, Roger J Hajjar, John V. Frangioni | ||
| 270 | Synthesis of Littorachalcone Ganesh L Kumar, George Kraus | ||
| 271 | Synthesis of structural probes for the PDE4 catalytic site Barbara Lindsay, David R Adams | ||
| 272 | Two-photon excited photodynamic therapy using water-soluble porphyrin dimers Milan Balaz, Hazel A. Collins, Marina K. Kuimova, Emma Dahlstedt, Mamta Khurana, Aliaksandr Karotki, David Phillips, Brian Wilson, Harry L. Anderson | ||
| 273 | Design and synthesis of some multitargeted ligands as potential antihypertensive agents Bishram Singh Chouhan, Mange Ram Yadav, Rajani Giridhar | ||
| 274 | Paper Withdrawn | ||
| 275 | Toward multivalent GPCR signaling from poly(amidoamine) dendrimer conjugates Yoonkyung Kim, Athena M. Klutz, Béatrice Hechler, Christian Gachet, Kenneth A. Jacobson | ||
| 276 | Hit to lead optimization of a series of 2-([2-amino]-4-phenyl-thiazole-5-carboxylic acid ethyl ester)carboxamides identified as A2A antagonists Gitte Mikkelsen, Anette Graven Sams, Mogens Larsen, Benny Bang-Andersen, Morten Langgaard, Tenna Juhl Schroeder, Lars Thorup | ||
| 277 | Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites Birgitte H. Kaae, Kasper Harpsøe, Alberto Contreras Sanz, Darryl S. Pickering, Per Sauerberg, Rasmus P. Clausen, Jette S. Kastrup, Tommy Liljefors, Ulf Madsen | ||
| 278 | Mechanism of interaction of multivalent antimicrobial peptide with model membranes Anne Young, Zhigang Liu, Chunhui Zhou, Neville R. Kallenbach | ||
| 279 | Novel water-soluble nocathiacin analogs as potent antibacterial agents Libo Xu, Kun Liu, Amy Farthing, Sheryl Debenham, Fengqi Zhang, Guo Q. Shi, James F. Dropinski, Peter T. Meinke, Christrine McCallum, Emily Hickey | ||
| 280 | Paper Withdrawn | ||
| 281 | ESI/MS study on sulfur containing ß-lactams and their interactions with glutathione Maya Kostova, Carey J. Myers, Monika Konaklieva | ||
| 282 | Synthesis and SAR of 4-(benzylideneamino)benzenesulfonamides as selective COX-2 inhibitors Shwu-Jiuan Lin, Li-Ming Yang | ||
| 283 | Synthesis and biological profile of substituted quinolines as potent 5-Lipoxygenase inhibitors Marc Gagnon, Christine Brideau, Elizabeth Cauchon, Anne Chateauneuf, Yves Ducharme, Richard Frenette, Richard W. Friesen, Sebastien Guiral, Pierre Hamel, Joseph A. Mancini, Marc Ouellet, David Percival, Angela Styhler, Elizabeth Wong | ||
| 284 | 1,3,5-Triazine derivatives with improved solubility for the treatment of inflammatory diseases Boulos Zacharie, Daniel Fortin, Shaun D. Abbott, Jean-François Bienvenu, Alan Cameron, Josée Cloutier, Jean-Simon Duceppe, Abdallah Ezzitouni, Karine Houde, Caroline Lauzon, Joël Lechasseur, Nancie Moreau, Valérie Perron, Nicole Wilb, Marie-Ève Fafard, Dannyck Gaudreau, Lilianne Geerts, Brigitte Grouix, François Sarra-Bournet, Lyne Gagnon, Christopher Penney | ||
| 285 | [1,4]Diazepine[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents Hong Gao, Gary Stack, Boyd L. Harrison, Hossein Mazandarani, Jean Zhang, Sachin Kalgonkar, Sharon Rosenzweig-Lipson, John Dunlop, Terry Andree, Lee Schechter | ||
| 286 | Synthesis and structure activity relationship of novel azaurazil and pyridopyramidine derivatives of arylpiperazine as potential and selective 5-Ht1a receptor agonists Vattoly J Majo, Jaya Prabhakaran, Lyudmila Savenkova, J. John Mann, J. S. Dileep Kumar | ||
| 287 | Synthesis of D-amino acid oxidase inhibitors and their effects on the plasma and brain levels of D-serine Bridget Duvall, Dana Ferraris, Yao-sen Ko, Ajit Thomas, Pavel Majer, Camilo Rojas, Takashi Tsukamoto, Kenji Hashimoto | ||
| 288 | Design, synthesis and in vivo results of chemically-modified antisense oligonucleotides targeting microRNA-122 Garth A. Kinberger, Stephanie Propp, Scott Davis, Susan Freier, Christine Esau, Eric E. Swayze, C. Frank Bennett, Balkrishen Bhat | ||
| 289 | Multifunctional proligands for Alzheimer's disease therapy Lauren E Scott, David E. Green, Tim Storr, Meryn L. Bowen, Michael Merkel, Gavin H Tansley, Harvey Schugar, Cheryl L. Wellington, Chris Orvig | ||
| 290 | Solid-phase synthesis of isotope-labeled 2-propyloctanoic acid, a therapeutic agent for stroke and Alzheimer's disease Jonathan Z. Ho, Cheng Tang, Matthew P Braun | ||
| 291 | Discovery and SAR study of a novel anti-Alzheimer compound family acting on APP Stéphane Burlet, Bénédicte Grasland, Marie-Ange Debreu-Fontaine, Marie-Eve Grosjean, André Delacourte, Patricia Melnyk | ||
| 292 | Synthesis and structure-activity relationships of novel, potent mixed lineage kinase (MLK) inhibitors for Alzheimer's disease Ming Tao, Chung Ho Park, Reddeppareddy Dandu, Allison Zulli, Kurt Josef, James L. Diebold, Diane E. Gingrich, Matthew Curry, Jean Husten, George Gessmen, Thelma Angeles, Robert L. Hudkins | ||
| 293 | Paper Withdrawn | ||
| 294 | Pyridinylaminohydantoins as small molecule BACE1 inhibitors: Exploration of the S3 pocket Ping Zhou, Jonanthan Bard, Rajiv Chopra, Kristi Yi Fan, Yun Hu, Yanfang Li, Ronald L. Magolda, Michael S. Malamas, Menelas Pangalos, Peter Reinhart, Jim Turner, Zheng Wang, Albert J Robichaud | ||
| 295 | Design, synthesis and SAR of potent statin-based β-secretase inhibitors: Exploration of P1 phenoxy and benzyloxy residues Marcus Bäck, Jonas Nyhlén, Ingemar Kvarnström, Åsa Rosenquist, Bertil Samuelsson | ||
| 296 | Pyrrolidines as conformationally constrained diaminopropanes: A versatile scaffold for potent inhibitors of BACE-1 Jason M. Guernon, Lorin A. Thompson III, John E. Macor, Andrew J. Tebben, Andrew Good, Catherine R. Burton, Donna M. Barten, Jovita Marcinkeviciene, Jeremy H. Toyn, Charlie Albright, Jodi K. Muckelbauer, Daniel Camac, Tatyana Zvyaga, James Grace, Kimberly Lentz, Kenneth M. Boy | ||
| 297 | Synthesis and SAR of hydroxyethylamine-based phenylcarboxyamides as BACE-1 inhibitors Yong-Jin Wu, Yunhui Zhang, Andrew Good, Lorin A. Thompson, Catherine R. Burton, Jeremy H Toyn, Charles F. Albright, John E. Macor | ||
| 298 | Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series Christina Ng Di Marco, Robert M. DiPardo, Ronald K. Chang, Kathy L. Murphy, Richard W. Ransom, Duane Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas Pettibone, Mark G. Bock, Scott D. Kuduk | ||
| 299 | Development of alpha-hydroxy amides as a novel class of Bradykinin B1 antagonists June J. Kim, Michael R. Wood, Kathy Schirripa, Mark G. Bock | ||
| 300 | Bradykinin B1 receptor antagonists: SAR studies of the aryl-piperidines on the cyclopropane carboxamide scaffold Jenny Wai, Scott D. Kuduk, Michael R Wood, Ronald K. Chang, Dong-Mei Feng, Kathy L. Murphy, Richard W. Ransom, Cuyue Tang, Thomayant Prueksaritanont, Roger M. Freidinger, Douglas Pettibone, Mark G. Bock | ||
| 301 | Synthesis and SAR study of a new series of Bradykinin B1 receptor antagonists containing allylic amines Qingyian Liu, Wenyuan Qian, Jian Jeffrey Chen, Christopher Fotsch, Nianhe Han, Aiwen Li, Chester Yuan, Gloria Biddlecome, Eileen Johnson, Carlo van Staden, Dianna Lester-Zeiner, Gordon Ng, Gondi Kumar, Randall W. Hungate, Benny C. Askew | ||
| 302 | Inhibitors of NF-Kappa B derived from thalidomide Bulbul Pandit, Esperanza Carcache de Blanco, Zhigen Hu, Pui Kai Li | ||
| 303 | Identification of a peptoid inhibitor of the proteasome that targets Sug2/Rpt4 Sub-unit Hyun-Suk Lim, Chase T. Archer, Di Cai, Deirdre Brekken, Thomas Kodadek | ||
| 304 | Synthesis and biological evaluation of 2-arylthiazolidine-4-caboxylic acid amides for melanoma and prostate cancer Yan Lu, Zhao Wang, Chien-Ming Li, Wei Li, James T. Dalton, Duane D. Miller | ||
| 305 | Trisubstituted isoalloxazines: A new class of G-quadruplex binding agents Mallesham Bejugam, Pravin Shirude, Sven Sewitz, Raphael Rodriguez, Shankar Balasubramanian | ||
| 306 | Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: Highly potent anti-inflammatory and cytoprotective agents Tadashi Honda, Chitra Sundararajan, Hidenori Yoshizawa, Xiaobo Su, Yukiko Honda, Karen T. Liby, Michael B. Sporn, Gordon W. Gribble | ||
| 307 | Nick-containing oligonucleotide as human Topoisomerase I inhibitor Ming Li, Tianhu Li | ||
| 308 | PMSA antibody-toxin conjugates as antiprostatic agents Danielle Falcone, Glenn J. Bubley, Graham Jones | ||
| 309 | Regulation of the topoisomerase II alpha gene using polyamides that binds to the inverted CCAAT box present in the promoter Jim Sexton, Hilary Mackay, Toni Brown, Minal Kotecha, Caroline O'Hare, Jerome Kluza, Daniel Hochhauser, John Hartley, Binh Nguyen, David Wilson, Moses Lee | ||
| 310 | New N-substituted phenoxazines as specific inhibitors of Akt in cancer cells Parimala B. Hanumesh, Bharathalaxmi Pulluru, Kuntebommanahalli N. Thimmaiah, Netkal M. Made Gowda | ||
| 311 | Synthesis and characterization of N-hexylamino phenoxazines as potential anticancer drugs Bharathalaxmi Pulluru, Parimala B. Hanumesh, Kuntebommanahalli N. Thimmaiah, Netkal M. Made Gowda | ||
| 312 | Discovery of YM155, a novel survivin suppressant for the treatment of cancer Isao Kinoyama, Akira Matsuhisa, Takahito Nakahara, Masahiro Takeuchi, Kenna Shirasuna, Tsuyoshi Minematsu, Norio Asai, Shunichiro Matsumoto, Kenichi Kawaguchi, Junichi Kazami, Akira Toyoshima, Aya Kita, Fumiko Tominaga, Minoru Okada, Mitsuaki Ohta | ||
| 313 | Enhancement of the anticancer activity of cladribine by application of the phosphoramidate protide approach Rocco Valente, Costantino Congiatu, Elisabeth Walsby, Kenneth Mills, Christopher McGuigan | ||
| 314 | Experimental and systems biology studies of the radioresistance of prostate carcinoma cells Ana Niciforovic, Jelena Djordjevic, Miroslav Adzic, Vesna Vucic, Petar M Mitrasinovic, Marija B. Radojcic | ||
| 315 | Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Scott C. Mayer, Annette L. Banker, Frank Boschelli, Li Di, Mark Johnson, Cynthia Hess Kenny, Girija Krishnamurthy, Kristina Kutterer, Franklin Moy, Susan Petusky, Malini Ravi, Diane Tkach, Hwei-Ru Tsou, Weixin Xu | ||
| 316 | Paper Withdrawn | ||
| 317 | Microwave-expediated synthesis of 5-aminosubstituted camptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1Ą Blair T Lapointe, Joelle Torregrossa, Kristen Bailey, Christopher Barone, Ryan T Coccia, Catherine Y Cote, Conor P Davern, Theresa A Dunstan, Benjamin J Durant, Nisal U Gajadeera, David A Garcia, Daniel I Gotleib, Andrea I Lebed, Emily A Lewis, Steven L Mathieu, Melissa L McNeel, Stephanie E Muser, Catherine M Norwood, Samantha M Rupert, Timothy F Siclari, Jason M Silverberg, Zachary P Thompson, Danielle Falcone, Glenn J. Bubley, Graham Jones | ||
| 318 | Novel duocarmycin-analog based antibody drug conjugate for targeted cancer therapy Vincent Guerlavais, Qian Zhang, Kilian Horgan, Sharon Boyd, Bilal Sufi, Liang Chen, Lynae Green, David Passmore, Janette Sung, Rangan Vangipuram, Lourdes Thevanayagam, Mohan Srinivasan, Mary Do, Rory Dai, Eilene Kwok, Colin Chong, Carol Soderberg, Chin Pan, Mary Huber, Peter Sattari, Chetana Rao, Shrikant Deshpande, Pina Cardarelli, David J. King, Sanjeev Gangwar | ||
| 319 | Pyrimido[4,5-b][1,4]diazepines as novel multitargeted inhibitors of receptor tyrosine kinases Zhiqin Ji, Vijaya Gracias, Irini Akritopoulou-Zanze, Daniel H. Albert, Keith B. Glaser, Patrick M. Marcotte, Pease Lori, Nirupama B. Soni, Kent D Stewart, Stevan W. Djuric, Steven K. Davidsen, Michael R. Michaelides | ||
| 320 | Synthetic methods for the preparation of novel ARQ501 human metabolites Rui-Yang Yang, Darin Kizer, Hui Wu, Erika Volckova, Xiusheng Miao, Khanh Nguyen, Syed Ali, Manish Tandon, Ron Savage, Mark A. Ashwell | ||
| 321 | Design and synthesis of carbocyclic nucleoside analogs as anticancer and antiviral drugs Naresh K Sunkara, Katherine L. Seley | ||
| 322 | Design, synthesis and preliminary evaluation of an antiestrogen-mitomycin C hybrid agent Robert N. Hanson, Edward Y. Hua, David C. Labaree, Richard B. Hochberg, John M. Essigmann, Robert G. Croy | ||
| 323 | Mechanism of action of bioactive tamoxifen conjugates Emily L. Rickert, Xinghua Long, Anton C. Peterson, Joseph P. Trebley, Melinda M. Morrell, Ken P. Nephew, Ross Weatherman | ||
| 324 | Synthesis and biological evaluation of cytotoxic decapeptide macrocycles Melinda R. Davis, Thomas J. Styers, Rodrigo A. Rodriguez, Shelli R McAlpine | ||
| 325 | Synthesis and cytotoxicity studies of novel sansalvamide A derivatives Yalda S. Mostofi, Suchitra Ravula, Stephanie Lapera, Melinda R. Davis, William S. Disman, Katerina Otrubova, Erinprit Signh, Shelli R McAlpine | ||
| 326 | Synthesis and application of fluorescence-labeled biotin-taxoid conjugate for the investigation into efficacious tumor-targeting drug delivery system Xianrui Zhao, Shuyi Chen, Jin Chen, Jingyi Chen, Iwao Ojima | ||
| 327 | Novel disulfide linkers for tumor-targeting drug delivery Xianrui Zhao, Jin Chen, Shuyi Chen, Stanislav Jaracz, Manisha Das, Iwao Ojima | ||
| 328 | Synthesis and evaluation of functionalized SWNT as transporter for tumor-targeting drug delivery Shuyi Chen, Jingyi Chen, Xianrui Zhao, Stanislaus S. Wong, Iwao Ojima | ||
| 329 | Rational design, synthesis, and bioassay of small molecules for inhibition of the mTOR signaling pathway Jun Yong Choi, Elzbieta S. Selinger, Lisa M. Ballou, Richard Z. Lin, Dale G. Drueckhammer | ||
| 330 | Design, synthesis and evaluation of tumor-targeting folate-taxoid conjugate Manisha Das, Iwao Ojima | ||
| 331 | Paper Withdrawn | ||
| 332 | Synthesis of 17-alpha-substituted arylvinyl estradiols and evaluation as ligands for the estrogen receptor ligand binding domain (ER-LBD) Robert N. Hanson, Sandra Olmsted, Pakamas Tongcharoensirikul, Emmett McCaskill, David C. Labaree, Richard B. Hochberg | ||
| 333 | Histone deacetylase inhibition activity of resveratrol and its analogs Didem Dayangac-Erden, Peruze Ayhan, Gamze Bora, Kemal Yelekci, Sevim Dalkara, Ayhan S. Demir, Hayat Erdem-Yurter | ||
| 334 | Discovery, optimization and biological evaluation of novel, potent and selective histone deacetylase (HDAC) inhibitors Nivedita D Namdev, Manish Tandon, Rao Akireddy, Hernan Orgueira, David Vensel, Ming Kung, Hui Wu, Patrick Hutchins, Magdi Moussa, Jeffrey Link, Yanbin Liu, Robb Nicewonger, Charles Bruseo, Julie Gorenstein, Enkeleda Nakuci, Denise McSweeney, Karen Bresciano, Yunxia Wang, Dennis France, Mark A. Ashwell | ||
| 335 | Design, synthesis and evaluation of the first highly selective sigma-2 receptor ligand Sanju Narayanan, Christophe Mesangeau, Jamal Shaikh, Rae R. Matsumoto, Jacques H. Poupaert, Christopher R. McCurdy | ||
| 336 | Discovery of 2-arylbenzoxazole carboxamides as 5-HT3 receptor antagonists Catherine M. Beer, Lisa H. Borden, Kevin L. Christensen, Svetlana Dobritsa, David J. Fairfax, Soshanna Isaacson, John P. Lindsay, Jun-Ho Maeng, David D. Manning, Liaqat Masih, Vadim V. Mozhaev, Dana A. Razzano, W. Martin Rennells, Justin Richardson, Timothy Rust, Alexander Usyatinsky, Zhicai Yang, Julianne V. Zaremba | ||
| 337 | Novel indole-3-carbinol-derived antitumor agents Jing-Ru Weng, Chen-Hsun Tsai, Samuel K. Kulp, Dasheng Wang, Chia-Hui Lin, Yihui Ma, Ching-Shih Chen | ||
| 338 | Lipophilic antitumor drug compounds: Cholesterol-modified camptothecins Yuehua Zhang, Lisa B. Brungardt | ||
| 339 | Study of conformationally biased oligodeoxyribonucleotides designed to induce bending and/or novel secondary structures in DNA Hisao Saneyoshi, Victor E. Marquez | ||
| 340 | Design, synthesis and evaluation of a potent class of spiroindoline pyrrolopyrimidines targeting Akt as anticancer agents Goss S. Kauffman, Joel T. Arcari, Chris Autry, Deborah Baker, Gaby Barbacci, Vincent Bernardo, Merin Boehm, Gary Borzillo, David Briere, Chiliu Chen, Tracey Clark, Kevin G. Coleman, Matthew Corbett, Kevin Freeman-Cook, Catherine Hulford, John Jakubczak, Shefali Kakar, Lissie Knauth, Chao Li, Jing Lin, Blaise Lippa, Yong Lu, Michael Luzzio, Eric Marr, Gary Martinelli, Matthew A Marx, Joel Morris, Kendra Nelson, Gonghua Pan, Jay Pandit, Kristina Rafidi, Shaughn Robinson, Eric Soderstrom, Kosta Tsaparikos, Patrick W Vincent, Liuqing Wei | ||
| 341 | Increase in oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to radiation Yong Zhao, Teresa Seefeldt, Wei Chen, Laura Carlson, Adam Stoebner, Sarah Hanson, Ryan Foll, Srinath Palakurthi, Xiangming Guan | ||
| 342 | N-Acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents Wei Chen, Teresa Seefeldt, Yong Zhao, Zhiling Zhang, Alan Young, Xiangming Guan | ||
| 343 | Evaluation of the effect of 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid (2-AAPA) on doxorubicin induced cardiotoxicity Sarah Hanson, Teresa Seefeldt, Qiangrong Liang, Xiangming Guan | ||
| 344 | Increase in oxidative stress via glutathione modulation as a novel approach to enhance cancer sensitivity to doxorubicin Teresa Seefeldt, Yong Zhao, Wei Chen, Laura Carlson, Adam Stoebner, Sarah Hanson, Ryan Foll, Srinath Palakurthi, Xiangming Guan | ||
| 345 | Interference of echinacea on cancer chemotherapy Jeremy Jensen, Fathi T. Halaweish, Christopher Chase | ||
| 346 | Synthesis and characterization of pyrrolidine dithiocarbamate-copper complex: Proliferation inhibition, cell cycle arrest, apoptosis induction activities on cisplatin-resistant neuroblastoma cells Haiyuan Zhang, Fangyu Peng | ||
| 347 | Synthesis and evaluation of novel bifunctional ligands for antibody targeted radiation cancer therapy and MRI Hyuna Song, Hyun-Soon Chong | ||
| 348 | Paper Withdrawn | ||
| 349 | Synthesis, characterization, and anticancer activity of new copper thiosemicarbazone compound holding ONNS quadridentate system Haiyuan Zhang, Fangyu Peng | ||
| 350 | Targeting cancer cells with boronated cyclic peptides for BNCT Erin J. Ziolkowski, Katrina A. Jolliffe, Louis M. Rendina | ||
| 351 | Toward "best-in-class" Hsp90 inhibitors: Design, biosynthesis and preclinical profiles Christine J Martin, Sabine Gaisser, William A Vousden, Lesley S Sheehan, Teresa Foster, Rose M Sheridan, Mohammad Nur-E-Alam, Nigel Coates, Steven J Moss, Christoph Beckmann, Barrie Wilkinson, Matthew A Gregory, Chris Prodromou, Laurence Pearl, Thomas Greiner, Niko Bausch, Ming Q Zhang | ||
| 352 | One-pot synthesis of dihydro-imidazo and imidazo-phenanthridinium DNA intercalating platforms as promising anticancer agents Leroy Cronin, Alexis D. C. Parenty | ||
| 353 | Development of potent inhibitors of B-Raf kinase Jianmei Wei, Ronald Wolin | ||
| 354 | Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogs as antitumor CDK inhibitors Ronghui Lin, Peter Connolly, George Chiu, Yang Yu, Shengjian Li, Stuart Emanuel, Lee Greenberger | ||
| 355 | Aurora kinase inhibitors: Lead structure identification from the Tetrahydrobenzo[b]thiophene class Alexander C. Backes, Matthias Baumann, Tilmann Brandstetter, Doris Hafenbradl, Roland Köstler, Lars Neumann, Joachim Vogt, Peter C. Sennhenn, Gerhard Müller, Gabriele Zybarth | ||
| 356 | P38 MAP kinase naphthyridinone inhibitors Rowena Ruzek | ||
| 357 | Design and SAR of pyrimidine-based inhibitors targeting the ABL-T315I mutation Elena Dneprovskaia, Jianguo Cao, Chun P. Chow, Richard Fine, Ehab Hanna, John Hood, Xinshan Kang, Boris Klebansky, Dan Lohse, Chi-Ching Mak, Andrew McPherson, Glenn Noronha, Moorthy S. S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng, Hong Zhu | ||
| 358 | Design and SAR of thiazole-based inhibitors for the ABL-T315I enzyme Chun P. Chow, Jianguo Cao, Elena Dneprovskaia, Richard Fine, Ehab Hanna, John Hood, Linda Hwang, Xinshan Kang, Boris Klebansky, Dan Lohse, Chi-Ching Mak, Andrew McPherson, Glenn Noronha, Moorthy S. S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng, Hong Zhu | ||
| 359 | Strategies involved in the construction of two series of novel potent inhibitors of ABL-T315I Binqi Zeng, Jianguo Cao, Chun P. Chow, Chi-Ching Mak, Elena Dneprovskaia, Richard Fine, Hong Gu, Ehab Hanna, John Hood, Xinshan Kang, Boris Klebansky, Ge Li, Dan Lohse, Andrew McPherson, Glenn Noronha, Joel Renick, Moorthy S. S. Palanki, Ved P. Pathak, Richard Soll, Suhan Tang, Hong Zhu | ||
| 360 | Azaindazole ureas as potent VEGFR/PDGFR multitargeted receptor tyrosine kinase inhibitors Yujia Dai, Kresna Hartandi, Daniel H. Albert, Jennifer J. Bouska, Gail T. Bukofzer, Cherrie K. Donawho, Keith B. Glaser, Jun Guo, Junling Li, Patrick A. Marcotte, Amanda M. Olson, Donald J. Osterling, Lori J. Pease, Niru B. Soni, Kent D. Stewart, Paul Tapang, David R. Reuter, Steven K. Davidsen, Michael R. Michaelides | ||
| 361 | Design and synthesis of c-met kinase inhibitors based on an in silico screen-derived lead Sung-Eun Kim, Zhen-Dan Shi, Megan Peach, Alessio Giubellino, Marc C Nicklaus, Donald Bottaro, Terrence R Burke Jr. | ||
| 362 | Design and synthesis of luminescent terbium(III) chelates: Application for kinase assay development George Guoliang Yi, Sukanta Bhattacharyya, Annegret Boge, Francisco Ramirez, J. Richard Sportsman | ||
| 363 | Discovery and SAR of a series of 3-[(6-piperidine-4-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridin-2-ones as IGF-1 receptor kinase inhibitors Peiying Liu, Upender Velaparthi, Mark D. Wittman, Mark G. Saulnier, K. Zimmermann, Xiaopeng Sang, David B. Frennesson, Francis Y. Lee, Joan Carboni, Ann Greer, Aixin Li, Ricardo Attar, Marco Gottardis, Zheng Yang, Dolatrai M. Vyas | ||
| 364 | Synthesis of cis-fused indolocarbazole pyran derivatives as multikinase inhibitors Françoise M. Perron-Sierra, Roy Golsteyn, Nathalie Kucharczyk, Patrick Casara, Céline Boucley | ||
| 365 | Discovery of ß-sulfonamide piperidine hydroxamates as potent and selective HER-2 sheddase inhibitors David M. Burns, Chunhong He, Yanlong Li, Peggy Scherle, Maryanne Covington, Max Pan, Richard Wynn, Sharon Turner, Jordan S. Fridman, Steve Friedman, Brian Metcalf, Wenqing Yao | ||
| 366 | Identification of multikinase inhibitor using a multistep computer aided approach Sivanesan Dakshanamurthy, Mikell Paige, Todd Hansen, Salimuddin Shah, Stephen Byers, Milton Brown | ||
| 367 | Nanomedicinal chemistry: Preparation of novel tyrosine kinase inhibitor-targeted linkers for nanoparticle targeting Robert N. Hanson, Kristin Bailey, Marah Elston, J. Adam Hendricks | ||
| 368 | Potent and selective PKC-θ inhibitors: Advancement from LI to LO Anthony S. Prokopowicz III, Charles L. Cywin, Georg Dahmann, Erick R. R. Young, Ronald L. Magolda, Mario G. Cardozo, Derek A. Cogan, Darren DiSalvo, John D. Ginn, Mohammed A. Kashem, John P. Wolak, Carol A. Homon, Thomas M. Farrell, Heather Grbic, Hanbo Hu, Paul V. Kaplita, Lisa H. Liu, Denice M. Spero, Deborah D. Jeanfavre, Kathy M. O'Shea, Della M. White, Joseph M. Woska Jr., Maryanne L. Brown | ||
| 369 | Novel pyrimidine alkynyl phenyl ureas as potent Tie-2 inhibitors Clifford D Jones, Kevin Blades, Matthew Box, Leonie Campbell, Paula Daunt, Richard Grant, Alison Griffen, Lorraine Hassall, Barry Hayter, Keith Johnson, Darren Jones, Jane Kendrew, Kieran Lennon, Richard WA. Luke, William McCoull, Linette Ruston, Michael L. Swain, Andy Wright, John A. Stawpert | ||
| 370 | Evolution of selective, potent, and orally bioavailable small molecule Tie-2 kinase inhibitors Philip R Olivieri II, Stephanie D Geuns-Meyer, Paul E Hughes, Brian K Albrecht, Steve Bellon, James Bready, Sean Caenepeel, Victor J Cee, Stuart C Chaffee, Angela Coxon, Maurice Emery, Jenne Fretland, Paul Gallant, Yan Gu, Brian L Hodous, Doug Hoffman, Rebecca E Johnson, Richard Kendall, Joseph L Kim, Alexander M Long, Michael Morrison, Vinod F Patel, Anthony Polverino, Paul Rose, Paul Tempest, Ling Wang, Douglas A Whittington, Huilin Zhao | ||
| 371 | Paper Withdrawn | ||
| 372 | Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase Karina Romero, Stephanie Geuns-Meyer, Paul Hughes, Annette Bak, Steve Bellon, James Bready, Sean Caenepeel, Victor J Cee, Stuart C Chaffee, Angela Coxon, Holly L. Deak, Maurice Emery, Jenne Fretland, Paul Gallant, Yan Gu, Brian L Hodous, Doug Hoffman, Rebecca E Johnson, Richard Kendall, Joseph L Kim, Jasmine Lin, Alexander M Long, Michael Morrison, Hanh N Nguyen, Philip R Olivieri II, Vinod F Patel, Anthony Polverino, David Powers, Paul Rose, Mary K Stanton, Ling Wang, Huilin Zhao | ||
| 373 | Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of VEGF-R2 and TIE-2 receptor tyrosine kinase Reddeppareddy Dandu, Allison L. Zulli, Edward Bacon, Ted Underiner, Candy Robinson, Hong Chang, Sheila Miknyoczki, Jennifer Grobelny, Bruce A. Ruggeri, Thelma S. Angeles, Lisa D. Aimone, Robert L. Hudkins | ||
| 374 | The impact of physicochemical properties on sensorial dynamic: The cooling sensation Stefan M. Furrer | ||
| 375 | Pharmaceutical applications of cooling agents Sara Encisco, Ahamindra Jain | ||
| 376 | Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives and related compounds as novel CC chemokine receptor 4 (CCR4) antagonists Noriyuki Kawano, Toru Kontani, Naoyuki Masuda, Yohei Koganemaru, Wataru Hamaguchi, Hiroyuki Kaizawa, Koji Kato, Susumu Igarashi, Hiroshi Nagata, Hiroshi Inami, Tadashi Terasaka, Noriko Ishikawa, Kazuhiro Yokoyama, Shinichi Ogino, Mitsuhiro Kondo, Makoto Takeuchi, Mitsuaki Ohta | ||
| 377 | Synthesis and SAR investigation of 3, 4-diamino derivatives of thiadiazole-1-oxides as CXCR1-CXCR2 dual antagonists Purakkattle Biju, Younong Yu, Cynthia Aki, Junying Zheng, Jianhua Chao, Michael P. Dwyer, Rindgen Diane, Richard Bond, James Jakway, Hongchen Qiu, R. William Hipkin, James Fossetta, Waldemar Gonsiorek, Hong Bian, Xuedong Fan, Carol Terminelli, Jay Fine, J. Robert Merritt, Zhenmin He, Gaifa Lai, Minglang Wu, Arthur Taveras | ||
| 378 | Synthesis and structure-activity relationships of heteroaryl-substituted 3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists Younong Yu, Michael P. Dwyer, Jianping Chao, Cynthia Aki, Jianhua Chao, Biju Purakkattle, Diane Rindgen, Richard Bond, Rosemary Mayer-Ezel, James Jakway, Hongchen Qiu, R. William Hipkin, James Fossetta, Waldemar Gonsiorek, Hong Bian, Xuedong Fan, Carol Terminelli, Jay Fine, Daniel Lundell, J. Robert Merritt, Zhenmin He, Gaifa Lai, Minglang Wu, Arthur G. Taveras | ||
| 379 | Imidazole derivatives as potent CXCR3 antagonists Xiaohui Du, Xiaoqi Chen, Jeffrey Mihalic, Jeffrey Deignan, Jason Duquette, An-rong Li, Bryan Lemon, Ji Ma, Shichang Miao, George Tonn, Tassie Collins, Julio Medina | ||
| 380 | Mono- and bicyclic small molecule antagonists of CXCR3 An-Rong Li, Michael G. Johnson, Jiwen Liu, Xiaoqi Chen, Xiaohui Du, Jeff Mihalic, Jeffrey Deignan, Darin J. Gustin, Jason Duquette, Zice Fu, Liusheng Zhu, Andrew P. Marcus, Phillipe Bergeron, Tassie Collins, Timothy Sullivan, Jay Danao, Julio C. Medina | ||
| 381 | Pyrido[1,2-a]pyrimidin-4-ones as potent CXCR3 antagonists Jason Duquette, Xiaohui Du, Johann Chan, Bryan Lemon, Tassie Collins, George Tonn, Julio Medina, Xiaoqi Chen | ||
| 382 | Identification of potential back-ups for clinical candidate CCR3 antagonist DPC-168 Qing Shi, Ui Tae Kim, Brian J. Vargo, Patricia K. Welch, Maryanne Covington, Nicole C. Stowell, Eric A. Wadman, Paul Davies, Kimberly A. Solomon, Swamy Yeleswaram, Danielle Graden, Ilona Kariv, Percy H Carter, Soo S. Ko, George V. De Lucca | ||
| 383 | Discovery of novel dopamine D3/D2 ligands for the treatment of schizophrenia György Domány | ||
| 384 | Design and synthesis of potent and selective fluorinated dopamine D3 receptor ligands Zhude Tu, Shihong Li, Michelle Taylor, Robert R. Luedtke, Robert H Mach | ||
| 385 | Anabolic activity and pharmacokinetic profiles of secreted frizzled-related protein-1 (SFRP-1) antagonists William J. Moore, Jeffrey C. Kern, Thomas J. Commons, Matthew A. Wilson, Gregory S. Welmaker, Eugene J. Trybulski, Keith Pitts, Girija Krishnamurthy, Barbara Stauffer, Ramesh Bhat, Shoichi Fukayama, Alana L. Upthagrove, Peter V. N. Bodine | ||
| 386 | Design, synthesis and biological activity of modulators of secreted frizzled related protein-1 (SFRP-1), an antagonist of the Wnt signaling pathway Thomas J. Commons, Richard P. Woodworth, Michael B. Webb, William J. Moore, Jeffrey C. Kern, Eugene J. Trybulski, Keith Pitts, Girija Krishnamurthy, Barbara Stauffer, Ramesh Bhat, Shoichi Fukayama, Alana L. Upthagrove, Peter V. N. Bodine | ||
| 387 | Diaryl sulfone sulfonamides as secreted frizzled-related protein-1 (SFRP-1) antagonists: SAR and optimization Jeffrey C. Kern, William J. Moore, Thomas J. Commons, Richard P. Woodworth, Matthew A. Wilson, Gregory S. Welmaker, Eugene J. Trybulski, Keith Pitts, Girija Krishnamurthy, Barbara Stauffer, Ramesh Bhat, Peter V. N. Bodine | ||
| 388 | Biophysical methods to interrogate the interactions of secreted frizzled-related proteins with small molecule antagonists Girija Krishnamurthy, Keith Pitts, William J. Moore, Matthew A. Wilson, Gregory S. Welmaker, Ariamala Gopalsamy, Peter V. N Bodine | ||
| 389 | Design and synthesis of fluorescent probes for the development of a binding assay for the identification of secreted frizzled-related protein-1 (SFRP-1) antagonists Gregory S. Welmaker, Matthew A. Wilson, William J. Moore, Jeffrey C. Kern, Eugene J. Trybulski, Ronald L. Magolda, Keith Pitts, Girija Krishnamurthy, Barbara Stauffer, Ramesh Bhat, Peter V. N. Bodine | ||
| 390 | Design, synthesis and biological activity of indane derivatives as modulators of secreted frizzled related protein-1 (SFRP-1), an antagonist of the Wnt signaling pathway Richard P. Woodworth, Thomas J. Commons, William J. Moore, Jeffrey C. Kern, Eugene J. Trybulski, Keith Pitts, Girija Krishnamurthy, Barbara Stauffer, Ramesh Bhat, Shoichi Fukayama, Alana L. Upthagrove, Peter V. N. Bodine | ||
| 391 | Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (SFRP-1) antagonist Ariamala Gopalsamy, Mengxiao Shi, Barbara Stauffer, Ramesh Bhat, Julia Billiard, Helga Ponce-de-Leon, Laura Seestaller-Wehr, Shoichi Fukayama, Annamarie Mangine, Robert Moran, Girija Krishnamurthy, Peter VN. Bodine | ||
| 392 | Iminooxothiazolidines as secreted frizzled related protein-1 (SFRP-1) antagonists Ariamala Gopalsamy, Mengxiao Shi, Barbara Stauffer, Ramesh Bhat, Julia Billiard, Helga Ponce-de-Leon, Laura Seestaller-Wehr, Shoichi Fukayama, Annamarie Mangine, Robert Moran, Girija Krishnamurthy, Peter VN. Bodine | ||
| 393 | Design, synthesis and SAR of potent substituted benzothiazole-cyclobutane histamine H3 receptor antagonists Chen Zhao, Minghua Sun, Thomas R. Miller, Timothy A. Esbenshade, Jill M. Wetter, Kennan C. Marsh, Jorge D. Brioni, Marlon D. Cowart | ||
| 394 | Design and synthesis of novel, potent and selective H3 antagonists based on the natural product conessine Jonathan A. Covel, Rena Hayashi, Brian Hofilena, Jason Ibarra, Michelle Pulley, Michael Weinhouse, Dipanjan Sengupta, Jonathan Duffield, Vincent J. Santora, Graeme Semple, Robert R. Webb, Marissa Suarez, John Frazer, William Thompson, Jeffrey Edwards, Erin Hauser, Kevin Whelan, Andrew Grottick | ||
| 395 | Synthesis and biological evaluation of novel and potent H3 antagonists with improved pharmacokinetic profiles Rena Hayashi, Jonathan A. Covel, Brian Hofilena, Jason Ibarra, Michelle Pulley, Michael Weinhouse, Dipanjan Sengupta, Jonathan Duffield, Vincent J. Santora, Graeme Semple, Robert R. Webb, Albert Ren, Guilherme Pereire, Marissa Suarez, John Frazer, William Thompson, Jeffrey Edwards, Erin Hauser, Kevin Whelan, Andrew Grottick | ||
| 396 | Paper Withdrawn | ||
| 397 | Development of potent histamine H3/H4 receptor ligands by the stereochemical diversity-oriented chiral cyclopropane-based conformational restriction strategy Mizuki Watanabe, Yuji Kazuta, Mitsuhiro Arisawa, Akira Matsuda, Satoshi Shuto | ||
| 398 | Histamine H3 antagonists with serotonin reuptake transporter inhibitor activity Kiev S. Ly, Michael A. Letavic, Leslie A. Gomez, Jill A. Jablonowski, John M. Keith, Jennifer M. Miller, Emily M. Stocking, Ronald L. Wolin, Ann J. Barbier, Jamin D. Boggs, Pascal Bonaventure, Brian Lord, Kirsten L. Miller, Sandy J. Wilson, Timothy W. Lovenberg, Nicholas I. Carruthers | ||
| 399 | Synthesis of DAG-lactones containing heterocyclic moieties: Small focused libraries in search of C1-specific domain interactions Saïd El Kazzouli, Nancy E. Lewin, Peter M. Blumberg, Vicror E. Marquez | ||
| 400 | Discovery of new generation of photodynamic therapeutics by an efficient combinatorial synthesis using porphyrin platform Mikki Vinodu, Diana Samaroo, Xin Chen, Charles Michael Drain | ||
| 401 | Analysis of sample purity and integrity data using structural fragments: Patterns in the stability of compounds stored as solutions Lynne P. Greenblatt, Dominick Mobilio, Ramaswamy Nilakantan | ||
| 402 | New alkyl and aryl analogs of amodiaquine: Design, synthesis and antimalarial activity Emilia Paunescu, Sophie Susplugas, Emmanuelle Boll, Richard A. Varga, Elisabeth Mouray, Ion Grosu, Philippe Grellier, Patricia Melnyk | ||
| 403 | Prion diseases and malaria: Similar SAR of an active Quinoline family Ralf Klingenstein, Patricia Melnyk, S. Rutger Leliveld, Adina Ryckebusch, Carsten Korth | ||
| 404 | Non-phosphate inhibitors of IspE, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy Anna K. H. Hirsch, Susan Lauw, Philipp Gersbach, W. Bernd Schweizer, Felix Rohdich, Wolfgang Eisenreich, Adelbert Bacher, François Diederich | ||
| 405 | Synthesis and biological activity of novel and potent C7 sancycline derivatives against Plasmodium falciparum Beena Bhatia, Haregewein Assefa, Laura Honeyman, Atul Verma, Michael Draper, Phillip Rosenthal, Jiri Gut, Lynn Garrity-Ryan, Mark L. Nelson | ||
| 406 | Releasable dual-drug conjugates of folic acid (EC0225): An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds Iontcho R. Vlahov, Hari Krishna R. Santhapuram, Yu Wang, Paul J. Kleindl, Fei You, Stephen J. Howard, Elaine Westrick, Joseph A. Reddy, Christopher P. Leamon | ||
| 407 | Chalcogen-containing cationic dyes for photosensitized cleavage of DNA with therapeutic applications Michael K. Gannon II, Jason J. Holt, Mao Ye, David J Donnelly, Tymish Y Ohulchanshyy, Bryan R Wetzel, Michael R. Detty | ||
| 408 | Gas-phase ion chemistry and tandem mass spectrometry for determination of alpha1 anti-trypsin inhibitor oxidation sites Harsha P. Gunawardena | ||
| 409 | Discovery and optimization of a small molecule series that induces a novel isotropic growth phenotype in C. Albicans Scott Collibee, Thomas Lila, Bradley Morgan, Penelope Chua, Matthew Hamilton, Takashi Nakai, Daniel Pierce, David J. Morgans Jr., Charles Vacin, David Clarke | ||
| 410 | Examination of the blood compatibility of heparinized carbon nanotubes Tae-Joon Park, Saravanababu Murugesan, Shaker Mousa, Jawed Fareed, Robert J. Linhardt | ||
| 411 | Effect of three volatile oils on percutaneous absorption of aconitine Li Yanjie, Ma Yunshu, Bai Yicen | ||
| 412 | Synthesis of gold nanoparticles bearing tumor antigens as novel anticancer therapeutics Andreas Sundgren | ||
| 413 | Targeted drug-delivery of an antibiotic bound to nanosized hydroxyapatite bone particles for treatment of bone injury Royce R Runner, Brian A Shapiro, James C McPherson III, Thomas B Buxton | ||
| 414 | Design and synthesis of heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors Joseph P. Sabatucci, Paige E. Mahaney, Eugene J. Trybulski, Jenifer Leiter, Grace Johnston, Yingru Zhang, Darlene C. Deecher, Oliver McConnell | ||
| 415 | SAR of the cycloalkanol ethylamine scaffold: 4-aminopiperidine reuptake inhibitors Paige E. Mahaney, Lori K. Gavrin, Fei Ye, Eugene J. Trybulski, Jenifer A. Bray, Grace H. Johnston, Jenifer Leiter, Elizabeth Koury, Darlene C. Deecher | ||
| 416 | SAR of the cycloalkanol ethylamine scaffold: N-Substituted piperazine reuptake inhibitors Paige E. Mahaney, Eugene J. Trybulski, Gary Stack, G. E. Morris Husbands, Jenifer A. Bray, Grace H. Johnston, Jenifer Leiter, Elizabeth Koury, Darlene C. Deecher | ||
| 417 | SAR of the cycloalkanol ethylamine scaffold: Alkyl analogs Lori Krim Gavrin, Paige E. Mahaney, Fei Ye, Joseph P. Sabatucci, Michael B. Webb, Eugene J. Trybulski, Jenifer A. Bray, Grace H. Johnston, Jenifer Leiter, Elizabeth Koury, Darlene C. Deecher | ||
| 418 | Substituted phenylpiperazinylethyl cycloalkanols as selective norepinephrine reuptake inhibitors An T. Vu, Stephen T. Cohn, Lori K. Gavrin, Joseph P. Sabatucci, Paige E. Mahaney, Alison N. Campbell, Arthur A. Santilli, Eugene J. Trybulski, Richard E. Mewshaw, Jenifer A. Bray, Grace H. Johnston, Jenifer Leiter, Elizabeth Koury, Darlene C. Deecher | ||
| 419 | SAR of the cycloalkanol ethylamine scaffold: Aminopyrrolidine and 3-aminopiperidine analogs Lori Krim Gavrin, Douglas J. Jenkins, Paige E. Mahaney, Justin K. Belardi, Eugene J. Trybulski, Jenifer A. Bray, Grace H. Johnston, Jenifer Leiter, Elizabeth Koury, Darlene C. Deecher | ||
| 420 | Paper Withdrawn | ||
| 421 | Practical asymmetric synthesis of potent NK1 antagonists Hon-Chung Tsui, Sunil Paliwal, Gregory A. Reichard, Dong Xiao, Cheng Wang, Michelle Laci Wrobleski, Sapna Shah, Ruth A. Duffy, Jean Lachowicz, Cynthia Morgan, Amin Nomeir, Geoffrey Varty, N-Y. Shih | ||
| 422 | Novel g-lactams as potent, selective and orally active NK1 antagonists Sunil Paliwal, Gregory A. Reichard, Sapna Shah, Michelle Laci Wrobleski, Cheng Wang, Carmine Stengone, Hon-Chung Tsui, Dong Xiao, Ruth A. Duffy, Jean E. Lachowicz, Fei Liu, Amin A. Nomeir, Geoffrey B. Varty, N-Y. Shih | ||
| 423 | Synthesis of a new anti-leishmanial lead structure by a novel Heck-type reaction Christina Reichwald, Orly Shimony, Nina Sacerdoti-Sierra, Charles L. Jaffe, Conrad Kunick | ||
| 424 | Discovery of 2-quinolyl-oxazoles as potent inhibitors of phosphodiesterase 4 Rongze Kuang, Ho-Jane Shue, David J. Blythin, Neng-Yang Shih, Li Xiao, Danlin Gu, Xiao Chen, John Schwerdt, Ling Lin, Pauline C. Ting, Xiaohong Zhu, Robert Aslanian, Daniel Prelusky, Ping Wu, Ji Zhang, Xiang Zhang, Chander Celly, Michael Minnicozzi, Motasim Billah, Peng Wang | ||
| 425 | Discrimination of (R)- and (S)-enantiomers of pyrroloquinolone derivatives by PDE5: A molecular docking/dynamics study Maulik R Patel, Tanaji T Talele | ||
| 426 | Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting alpha4-beta1 and alpha4-beta7 receptor antagonists Jefferson W. Tilley, Achyutharao Sidduri, Jian Ping Lou, Pam Rossman, Nadine Tare, Gary Cavallo, Aruna Railkar, Louise Gerber, Karl Frank, Louis Renzetti | ||
| 427 | Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists Marc-Raleigh Brescia, Laura L. Rokosz, Andrew G. Cole, Tara M. Stauffer, John M. Lehrach, Doulas S. Auld, Ian Henderson, Maria L. Webb | ||
| 428 | Development of prostaglandin D2 receptor antagonist based on a tetrahydropyridoindole scaffold Christian Beaulieu, Daniel Guay, Zhaoyin Wang, Yves Leblanc, Patrick Roy, Claude Dufresne, Robert Zamboni, Carl Berthelette, Stephen Day, Nancy N. Tsou, Danielle Denis, Gillian Greig, Marie-Claude Mathieu, Erika Vigneault, Gary O'Neill | ||
| 429 | Structure-activity relationship of 1,2,3,5-tetrasubstituted indoles as potent microsomal prostaglandin E2 synthase-1 inhibitors Sébastien Laliberté, Hélène Juteau, Yves Gareau, Renee Aspiotis, Erich L. Grimm, Marc Blouin, D. Bruce Mackay, Richard W. Friesen, Diane Ethier, Jocelyne Guay, Chi-Chung Chan, Denis Riendeau | ||
| 430 | Synthesis and structure-activity relationships of biarylimidazole derivatives as inhibitors of the microsomal prostaglandin E2 synthase-1 Hélène Juteau, Tom Y-H. Wu, Yves Ducharme, Richard W. Friesen, Sebastien Guiral, Lynn Dufresne, Myriam Salem, Hugo Poirier, Daigen Xu, Laurent Audoly | ||
| 431 | QSAR study of tacrine derivatives using variable selections Yongnam Lee, Youngae Jung, Mankil Jung | ||
| 432 | Structure guided virtual screening against dihydropteroate synthase Kirk E. Hevener, Iain Kerr, Mi Kyung Yun, Jianjun Qi, Stephen W. White, Richard E. Lee | ||
| 433 | Structure-based virtual screening: The discovery of novel inhibitors of hepatitis C virus NS5B RNA dependent RNA polymerase Su Yeon Kim, Jae Hong Shin, Kyoung Tai No | ||
| 434 | Computational investigation of direct antitumor cell activity of novel bisphosphonates Michael P. Hudock, Yonghui Zhang, Kilannin Krysiak, Fenglin Yin, Rong Cao, Yongcheng Song, Ermond van Beek, Socrates Papapoulos, Eric Oldfield | ||
| 435 | Synthesis and profiling of a new multiple kinase inhibitor chemotype Anne-Marie Egert, Simone Kohfeld, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Daniel W. Zaharevitz, Conrad Kunick | ||
| 436 | Synthesis and properties of novel stigmasterol-based cationic liposomes Zhiping Le, Jia Qian, Fei Yu, Shaobo Deng, Roger Ruan, Paul Chen | ||
| 437 | Synthesis, structure and solution chemistry of 3-thia-uracil Jian Gao, Lei Shi, Ryan Ermis, Lawton Seal, Duncan Aust, Braham Shroot | ||
| 438 | Design and synthesis of unnatural DNA containing ring expanded purine analogs Orrette R Wauchope, Dr. Zhibo Zhang, Dr. Katherine Seley-Radtke | ||
| 439 | Synthesis of conformationally locked versions of puromycin as tools to understand the role of furanose conformation in the peptidyl transfer reaction Hisao Saneyoshi, Yongseok Choi, Peter Strazewski, Victor E. Marquez | ||
| 440 | Efficient one-pot synthesis of chiral polysubstituted morpholines Rana Adnan Bilbeisi, Nicolas Moitessier | ||
| 441 | Paullones are rearranged to 11H-indolo[3,2-c]quinoline-6-carboxylic acids by a novel ring contraction reaction Anja Becker, Simone Kohfeld, Lutz Preu, Tanja Pies, Daniel W. Zaharevitz, Conrad Kunick | ||
| 442 | Syntheses of UDP-GlcNYn, UDP-GalNYn and several analogs with utility to analyze sugar-transferase protein substrates Ganesha Rai, Craig J Thomas | ||
| 443 | Synthesis of novel PNA building blocks for strain-promoted "click" chemistry J. S. Taylor, Poulomi Sengupta | ||
| 444 | Toward the synthesis of Clathculins A and B Susan Gail Brown | ||
| 445 | Utilizing a diazirine and alkyne containing probe in a proof of principle study to investigate small molecule interactions across the proteome Christopher A. LeClair, William A. Prinz, Sumana Raychaudhuri, Craig J. Thomas | ||
| 446 | Cholesterol lowering drugs inhibit Staphylococcus aureus virulence Eric Oldfield | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007