| MEDI | Sunday, August 19, 2007 | ||
7:00 PM-9:00 PM BCEC -- Exhibit Hall - B2, Poster | |||
Poster Session | |||
| Organizer: | James R. McCarthy | ||
| 29 | 3-(Amino)alkoxy indoles: Novel class of centrally acting anti-obesity agents Ramakrishna V. S. Nirogi, Anand V Daulatabad, Narendra Varma Gaddiraju, Parandhama Gudla, Mallesh Junnuri, Srinivasulu Kota, Rama Sastry Kambhampati, Anil K. Shinde | ||
| 30 | Nonpsychotropic biaryl cannabinoid agonists Karin Worm, Q. Jean Zhou, Gabriel Stabley, Robert N. DeHaven, Nathalie C. Conway-James, Christopher J LaBuda, Michael Koblish, Patrick J Little, Roland E. Dolle | ||
| 31 | Synthesis of (-)-Δ9-tetrahydrocannabinol and (-)-Δ9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs Spyros P. Nikas, Ganesh A. Thakur, Damon Parish, Shakiru O. Alapafuja, Marilyn A Huestis, Alexandros Makriyannis | ||
| 32 | Deuterated and tritiated enantiomers of CP55,940 as novel probes of cannabinoid receptors Kejun Cheng, Klaus Gawrisch, Kenner C. Rice | ||
| 33 | Synthesis of isotopically labeled 2-pyridinyloxyisobubanoic acid, a building block for CB-1 inhibitors as drug candidates for obesity treatment Jonathan Z. Ho, Matthew P Braun | ||
| 34 | Synthesis and biological evaluations of carbamoyl oxime analogs of the cannabinoid receptor-1 (CB1) anatagonist SR141716 Sung-Hwa Yoon, Hee-yeon Kim, Hyun-Ji Kim, Hyo-jae Jung | ||
| 35 | Synthesis and SAR of Diaryl cyclohexene carboxamides as potent and orally active CB1 antagonists Charles L. Jayne, Yan Xia, H. Vaccaro, Samuel Chackalamannil, William Greenlee, George Boykow, Ruth A. Duffy, Timothy Kowalski, Xiaoming Cui | ||
| 36 | Synthesis and SAR of derivatives from 2, 3-dihydro-1H-spiro [isoquinoline-4, 4'-piperidine] as MC4R agonists for the treatment of obesity Jian Liu, Tianying Jian, Iyassu K. Sebhat, Rui Tang, David H. Weinberg, Tanya MacNeil, Angeles Cabello, Airu S. Chen, Howard Y. Chen, Cherrie A. Shepherd, Alison Strack, R. Miller, Ralph Stearns, Zhesheng Chen, Tom Holt, Tung M. Fong, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 37 | Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands Qingmei Hong, Raman K. Bakshi, James Dellureficio, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, Aurawan Vongs, Charles I. Rosenblum, David H. Weinberg, Qianping Peng, Constantin Tamvakopoulos, Randy R. Miller, Ralph A. Stearns, Doreen Cashen, William J. Martin, Airu S. Chen, Joseph M. Metzger, Howard Y. Chen, Alison M. Strack, Tung M. Fong, D. Euan MacIntyre, Lex H. T. Van der Ploeg, Arther A. Patchett, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 38 | Potent and orally bioavailable nonpeptidyl melanocortin subtype-4 receptor modulators: Syntheses, SAR and pharmacokinetics Liangqin Guo, Zhixiong Ye, Iyassu K. Sebhat, Feroze Ujjainwalla, Heather L. Sings, David H. Weinberg, Rui Tang, Tanya MacNeil, Constantin Tamvakopoulos, Qianping Peng, Euan MacIntyre, Lex H. T. Van der Ploeg, Mark T. Goulet, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 39 | Aminobenzimidazoles as potent Melanin Concentrating Hormone (MCH)-R1 antagonists T K Sasikumar, Li Qiang, Duane A Burnett, William J Greenlee, Brian E Hawes, Timothy J Kowalski, Kim O'Neill, Brian D Spar, Blair Weig | ||
| 40 | Tetrahydro carbazoles: Novel, potent and selective 5-HT6 receptor antagonists Rama Sastry Kambhampati, Jagadish B. Konda, Prabhakar Kothmirkar, Trinath R. Bandyala, Sivasekhar NK. Yarra, Sobhanadri Arepalli, Anil K. Shinde, Ramakrishna V. S. Nirogi | ||
| 41 | Novel 1-(arylsulfonyl)-3-(piperidinylmethyl)-1H-indoles as potent and selective 5-HT6 antagonists Ping Zhou, Yanfang Li, Boyd L. Harrison, Guo Ming Zhang, Deborah Smith, Michael G. Kelly, Lee Schechter, Albert J Robichaud | ||
| 42 | SUVN-504: Potent and selective high brain penetrating 5-HT6 receptor antagonist Gopinadh Bhyrapuneni, Nageswararao Muddana, Koteshwara Mudigonda, Vishwottam N. Kandikere, Ramakrishna V. S. Nirogi | ||
| 43 | Aminoalkyl indoles: Novel, potent and highly selective 5-HT6 receptor antagonists Anil K. Shinde, Amol D. Deshpande, Anil K. Chindhe, Rajesh Kumar Badange, Kameswara R. Karuturi, Narasimha Reddy P. Gangadasari, Raja Rajeswari Katta, Ramakrishna V. S. Nirogi | ||
| 44 | Conformationally restricted piperazines: Novel class of potent and selective 5-HT6 receptor ligands Ramakrishna V. S. Nirogi, Amol D. Deshpande, Adi R. Dwarampudi, Venugopala Rao Bhatta, Laxman Kota, Ravichandra R. V. Vangavarugu, Rama Sastry Kambhampati, Anil K. Shinde | ||
| 45 | Small-molecule Y2 receptor antagonists: Identification of a novel and potent series using pharmacophore-based virtual screening Mark Seierstad, Pascal Bonaventure, Lisa Dvorak, Brian Lord, Kirsten L. Miller, S. Timothy Motley, Diane H. Nepomuceno, Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Chandra Shah, Devin M. Swanson, Victoria D. Wong, Frank U. Axe, Timothy W. Lovenberg, Nicholas I. Carruthers | ||
| 46 | Discovery and optimization of imidazoline derivatives, a potent, orally active neuropeptide Y Y5 receptor antagonist Makoto Ando, Nagaaki Sato, Shiho Ishikawa, Makoto Jitsuoka, Keita Nagai, Tsuyoshi Nagase, Hirobumi Takahashi, Aya Sakuraba, Hiroyasu Tsuge, Mioko Hirayama, Junko Ito, Hisashi Iwaasa, Hiroko Matsushita, Akira Gomori, Satoshi Mashiko, Akane Ishihara, Naoko Fujino, Sachiko Tanaka, Tomoyuki Ohe, Kiyoshi Tadano, Takahiro Fukuroda, Yasuyuki Ishii, Akio Kanatani, Takehiro Fukami | ||
| 47 | Synthesis and SAR of thiophene acid-mimetics as PTP1B inhibitors Eva Binnun, Zhao-Kui Wan, Bruce Follows, Steven J. Kirincich, Douglas Wilson, Wei-Xin Xu, Diane Joseph-McCarthy, Junjun Wu, Michael J. Smith, Yanling Zhang, May Tam, Dave Erbe, Steve Tam, Eddine Saiah, Jinbo Lee | ||
| 48 | Discovery and synthesis of nipecotic amide as novel, potent and selective 11ß-HSD-1 inhibitors Jincong Zhuo, Meizhong Xu, Colin Zhang, Dingquan Qian, Yanlong Li, Reid Huber, Maryanne Covington, Cindy Marando, Brian Metcalf, Wenqing Yao | ||
| 49 | Novel analogs as 11β-HSD1 inhibitors Unmesh Shah, Craig D. Boyle, Samuel Chackalamannil, Hana Baker, Timothy Kowalski, Lili Zhang, Giuseppe Terracina | ||
| 50 | B-keto sulfonamides as selective inhibitors of the 11b-HSD1 Manus Ipek, Jason Xiang, Lihren Chen, Nelson Huang, Jim Li, Wei Li, Tarek Mansour, John C McKew, Jill Nunez, Vipin Suri, Tam May, Steve Tam, James F Tobin, Charlie Wu, Yuzhe Xing, Xin Xu, Yanling Zhang | ||
| 51 | Discovery and biological evaluation of novel benzamide derivatives as potent 11b-HSD1 inhibitors for the treatment of type II diabetes Lisa D. Julian, Tracy Bostick, Sebastien Caille, Hon Chan, Michael Degraffenreid, Xiao He, Randall W. Hungate, Juan Jaen, Ben Jiang, Jacob Kaizerman, Jinsong Liu, Dustin McMinn, Jay P. Powers, Yosup Rew, Athena Sudom, Daqing Sun, Hua Tu, Stefania Ursu, Zhulun Wang, Xuelei Yan, Qiuping Ye | ||
| 52 | Discovery and SAR of novel derivatives as 11β-hydroxysteroid dehydrogenase type 1 inhibitors Claire M. Lankin, Craig D. Boyle, Samuel Chackalamannil, Unmesh Shah, Hana Baker, Timothy Kowalski, Lili Zhang, Giuseppe Terracina | ||
| 53 | Synthesis and biologic evaluation of selective inhibitors of 11β-HSD1 as a potential treatment for metabolic disorders Santhosh F. Neelamkavil, Craig D. Boyle, Samuel Chackalamannil, Hana Baker, Timothy Kowalski, Lili Zhang, Giuseppe Terracina | ||
| 54 | Syntheses and SAR of piperidin-3-yl ureas as potent and selective 11β-HSD-1 inhibitors Yun-Long Li, Lori Bostrom, Jincong Zhuo, Yanlong Li, Maryanne Covington, Reid Huber, Brian Metcalf, Wenqing Yao | ||
| 55 | Discovery and optimization of arysulfonamide as a novel class of 11beta-HSD1 inhibitors Daqing Sun, Michael DeGraffenreid, Xiao He, Juan Jaen, Jay P. Powers, Xuelei Yan, Yongmei Di, Hua Tu, Stefania Ursu, Ji Ma, Shichang Miao, Liang Tang, Qiuping Ye, Athena Sudom, Zhulun Wang | ||
| 56 | Azapaullones: GSK-3 inhibitors activating beta cell protection and proliferation Hendrik Stukenbrock, Rainer Mussmann, Matthias Austen, Marcus Geese, Simone Kegel, Olivier Lozach, Laurent Meijer, Conrad Kunick | ||
| 57 | Synthesis, SAR and evaluation of C-aryl glucosides as sodium-glucose cotransporter inhibitors for the treatment of type 2 diabetes Wei Meng, William N. Washburn, Bruce A. Ellsworth, Ravindar N. Girotra, Peggy J. McCann, Prashant P. Deshpande, Annie J. Pullockaran, Manorama Patel, Philip M. Sher, Gang Wu, Scott A. Biller, Deborah L. Hagan, Songping Han, Ashish Khanna, Joseph R. Taylor, Li Xin, John R. Wetterau, Jean M. Whaley | ||
| 58 | Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide 1 He Meng, Krishna Kumar | ||
| 59 | Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 (GPR40) agonists Fengbin Song, Songfeng Lu, Joe Gunnet, Jun Z. Xu, Pam Wines, Yin Liang, Chris Baumann, Jim Lenhard, William V. Murray, Keith T. Demarest, Gee-Hong Kuo | ||
| 60 | Dipeptidyl peptidase IV inhibitors incorporating fused azoles as effective amide isosteres Hong Dong, Wallace T. Ashton, Rosemary M. Sisco, Kathryn A. Lyons, Huaibing He, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Xiaoping Zhang, Nancy A. Thornberry, Ann E. Weber | ||
| 61 | Paper Withdrawn | ||
| 62 | Synthesis, SAR, and in vivo efficacy of novel GPR119 agonists with a 4-[3-(4-methanesulfinylphenoxy)propyl]-1-Boc-piperidine core Matthew C. T. Fyfe, Adam J. Babbs, Lisa S. Bertram, Stuart E. Bradley, Sheila M. Doel, Smita Gadher, William T. Gattrell, Revathy P. Jeevaratnam, John F. Keily, James G. McCormack, Hilary A. Overton, Chrystelle M. Rasamison, Christine Reynet, Philip J. Rushworth, Colin P. Sambrook Smith, Vilas K. Shah, David F. Stonehouse, Simon A. Swain, Jonathan R. White, Peter S. Widdowson, Geoffrey M. Williams, Martin J. Procter | ||
| 63 | Nε-methanesulfonyl-lysine as a nonhydrolyzable functional surrogate for Nε-acetyl-lysine Nuttara Jamonnak, David G. Fatkins, Lanlan Wei, Weiping Zheng | ||
| 64 | Design, synthesis and bioactivity of novel inhibitors of E. coli Aspartate Transcarbamoylase Joby Eldo, Sabrina Heng, Evan R. Kantrowitz | ||
| 65 | Thermal stability and activity of fluorinated single-isoleucine mutants of chloramphenicol acetyltransferase Natalya Voloshchuk, Man Xia Lee, Wan Wen Zhu, Ismet Caglar Tanrikulu, Jin K. Montclare | ||
| 66 | Analogs of orotidine monophosphate (OMP): Their effect on the activity of OMP decarboxylase Srinath Thirumalairajan, Stephen L. Bearne | ||
| 67 | Assessing the role of tyrosine 190 in the catalytic mechanism of hamster N-acetyltransferase 2 by site-directed mutagenesis, pre-steady state and steady state kinetic studies Xin Zhou, Li Liu, Patrick E. Hanna, Carston R. Wagner | ||
| 68 | Development of C2-symmetric, active site-directed inhibitors for Cystathionine beta-Synthase Christopher D. McCune, Weijun Shen, Woo Jin Chung, David B. Berkowitz | ||
| 69 | Discrimination of carbonic anhydrase isozymes by the excited-state lifetimes of polymerized liposome incorporated lanthanide ions Adekunle Elegbede, Manas Haldar, Sumathra Manokaran, Sanku Mallik, D. K. Srivastava | ||
| 70 | Design, synthesis and chemical reactivity of 1,4-naphtoquinone derivatives as cysteine protease irreversible inhibitors Claudia Valente, Rui Moreira, Rita C. Guedes, Jim Iley, Mohammed Jaffar, Kenneth T. Douglas | ||
| 71 | Synthetic approaches to amino acid cyclobutanone derivatives Preeti Kataria, Nick Armoush, Daniel P. Becker | ||
| 72 | Phosphonosulfonates are potent inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus Yongcheng Song, George Liu, Fenglin Yin, Victor Nizet, Eric Oldfield | ||
| 73 | Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase James M. Hogan, Sylvine Deprele, Boris A. Kashemirov, BL Barnett, Artem Evdokimov, Jim Dunford, R. Graham G. Russell, Frank H. Ebetino, Charles E. McKenna | ||
| 74 | Structure-based design of reversible peptides inhibitors of Factor VII-a Cristina C. Clement, Lisa Gingold, Manfred Philipp | ||
| 75 | 7-Fluoroindazoles as potent and selective factor Xa inhibitors Yu-Kai Lee, Tianbao Lu, Daniel J. Parks, Tho V. Thieu, Thomas Markotan, Wenxi Pan, David F. McComsey, Karen L. Milkiewicz, Carl Crysler, Nisha Ninan, Marta C. Abad, Edward C. Giardino, Bruce E. Maryanoff, Bruce P. Damiano, Mark R. Player | ||
| 76 | Discovery of N-{(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride (DT-831j): A novel, potent and orally active direct inhibitor of factor Xa Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya, Kenji Yoshikawa, Masatoshi Nagamochi, Shozo Kobayashi, Satoshi Komoriya, Aki Yokomizo, Ryo Muto, Mitsuhiro Yamaguchi, Ken Osanai, Makoto Suzuki, Hideyuki Kanno | ||
| 77 | Induced polarization in drug-receptor binding: Contribution to the binding affinity of a meta-chlorobenzyl side chain in the S1 pocket of thrombin Menshawy Mohamed, Bernhard Baum, Marek Freindorf, Gerhard Klebe, David G. Hangauer | ||
| 78 | Drug target validation using transcription profiling and reverse-engineered gene networks Melissa M. Dominguez, Elissa Cosgrove, Yingchun Zhou, Eric D. Kolaczyk, Scott E. Schaus, Timothy S. Gardner | ||
| 79 | Imidazole-acetamide substituted piperazinylbenzimidazole antagonists of the Gonadotropin Releasing Hormone receptor Joseph T. Lundquist IV, John F. Mehlmann, Lloyd Garrick, Jeffrey C. Pelletier, Jay Wrobel, Joshua E. Cottom, Linda Shanno, Murty V. Chengalvala, Christine Huselton, Irene B. Feingold | ||
| 80 | Simultaneous biological optimization and structural simplification of a pendant heterocyclic thiobenzimidazolone on a series of 2-phenyl-4-(piperazin-1-yl)benzimidazole antagonists of the Gonadotropin Releasing Hormone Receptor Jeffrey C. Pelletier, Murty V. Chengalvala, Joshua E. Cottom, Lloyd Garrick, James Jetter, Wenling Kao, Linda Shanno, Jay Wrobel | ||
| 81 | Design, synthesis and SAR of uracil diamines as potent GnRH receptor antagonists Charles Huang, Warren Wade, Yun-Fei Zhu, Chen Chen, Zack Guo, Yongsheng Chen, Scott Struthers, Martin W. Rowbottom, Jamie Rueter, Duncan Wu, Joann Xie, John Saunders | ||
| 82 | Parallel synthesis of substituted pyridones for use as Gonadotropin Releasing Hormone (GnRH) antagonists Daniel Green, Jeffrey C. Pelletier, Murty V. Chengalvala, Joshua E. Cottom, Linda Shanno | ||
| 83 | Substituted 5-oxopyrazoles as HCV polymerase inhibitors Tong Wang, Dansu Li, Gerald W. Shipps Jr., Kristin E. Rosner, Patrick Curran, Yongqi Deng, Janeta Popovici-Muller, Alan B Cooper, Viyyoor Girijavallabhan | ||
| 84 | HCV NS3 serine protease inhibitors: Discovery of carbamate derived new P4 capping moieties with improved profile A. Arasappan, A. I. Padilla, F. Bennett, S. L. Bogen, Kevin X Chen, S. Hendrata, Y. Huang, Edwin Jao, W. Pan, R. E. Pike, S. Ruan, M. Sannigrahi, S. Venkatraman, B. Vibulbhan, Wanli Wu, W. Yang, A. K. Saksena, V. Girijavallabhan, Xiao Tong, K-C. Cheng, N-Y. Shih, F. G. Njoroge | ||
| 85 | Molecular docking and 3-D-QSAR studies on benzimidazole series of Hepatitis C virus NS5B polymerase inhibitors Pallav D Patel, Tanaji T Talele | ||
| 86 | Discovery of new P4 (esters, acids, ketones) extended ketoamide inhibitors of the HCV NS3 serine protease with improved potency and PK profile Stephane L Bogen, Weidong Pan, S. Ruan, Ashok Arasappan, Frank Bennett, Kevin Chen, S. Hendrata, Y. Huang, Edwin Jao, Y-T. Liu, R. Lovey, Latha Nair, A. I. Padilla, R. Pike, Patrick Pinto, M. Sannigrahi, Francisco Velazquez, S. Venkatraman, B. Vibulbhan, Wanli Wu, W. Yang, A. K. Saksena, Viyyoor Girijavallabhan, Xiao Tong, K-C. Cheng, N-Y. Shih, F. George Njoroge | ||
| 87 | Novel HCV protease inhibitors: Using acyl-sulfamides to form P1-P1′ macrocycles Jason P Shanley, Hui-Ju Chen, Charles W Hutchins, Dale J. Kempf, Larry L. Klein, Kevin Kurtz, Alex Konstantinidis, Keith F. McDaniel | ||
| 88 | Discovery of Novel P4 capped sulfonamide derived inhibitors of HCV NS3 protease Srikanth Venkatraman, Wanli Wu, Melissa Blackman, Ashok Arasappan, Frank Bennett, Stephane L Bogen, Kevin X Chen, Siska Hendrata, Yuhua Huang, Edwin Jao, Latha Nair, A. I. Padilla, Weidong Pan, R. Pike, Patrick Pinto, S. Ruan, Mousumi Sannigrahi, Francisco Velazquez, Bancha Vibulbhan, Weiying Yang, Anil Saksena, Viyyoor Girijvallabhan, Xiao Tong, K-C. Cheng, Neng-Yang Shih, F. George Njoroge | ||
| 89 | Synthesis and anti-HIV-RT activity of a series of indole alkyl sulfones Xufang Zhang, Vandna Munshi, Dan diStefano, Linda Ecto, Peter J. Felock, Meizhen Feng, Jessica A. Flynn, MingTain Lai, Yuexia Liang, Meiquing Lu, Mike Miller, Greg Moyer, Rebecca A. Poehnelt, Sridhar Prasad, Rosa I. Sanchez, William Schleif, Maricel Torrent, Sinoeun Touch, BangLin Wan, Theresa M. Williams | ||
| 90 | Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres G. S. Kiran Kumar Reddy, Akbar Ali, Madhavi N. L. Nalam, Saima Ghafoor Anjum, Hong Cao, Robin S. Nathan, Celia A. Schiffer, Tariq M. Rana | ||
| 91 | Potent HIV integrase inhibitor with excellent pharmacokinetics Melissa Egbertson, Michelle Kuo, Debra Perlow, Marie Langford, Jeffrey Melamed, John Wai, Joseph Vacca, Audrey Wallace, Yvonne Leonard, Daria J. Hazuda, Peter J. Felock, Kara Stillmock, William Schleif, Lori J. Gabryelski, Gregory Moyer, Joan Ellis, Lixia Jin, Steven D. Young | ||
| 92 | Molecular modeling, synthesis, and in vitro/in vivo evaluation of 1,4-dihydropyridine, pyrrole, and benzopyran analogs as HIV-1 RT inhibitors Tanaji T Talele, Dinesh Manvar, Kena Raval, Virendra N Pandey, Anamik Shah | ||
| 93 | Phthalimide-containing hydrazides and amides as diketo acid-class HIV-1 integrase inhibitors Xue Zhi Zhao, Elena A. Semenova, B. Christie Vu, Chenzhong Liao, Marc C Nicklaus, Stephen H. Hughes, Yves Pommier, Terrence R. Burke Jr. | ||
| 94 | Design, synthesis, and biological evaluation of HIV-1 protease inhibitors incorporating phenyloxazolidines as novel P2 ligands Akbar Ali, G. S. Kiran Kumar Reddy, Hong Cao, Saima Ghafoor Anjum, Madhavi N. L. Nalam, Celia A. Schiffer, Tariq M. Rana | ||
| 95 | Discovery of novel HIV-1 integrase inhibitors by pharmacophore search Chenzhong Liao, Christophe Marchand, Yves Pommier, Marc C. Nicklaus | ||
| 96 | Synthesis and anti-HIV activities of fatty acyl derivatives of 2',3'-dideoxy-3'-thiacytidine Hitesh Kumar Agarwal, Michael Hanley, Gustavo F. Doncel, Keykavous Parang | ||
| 97 | Synthesis and evaluation of bis(fatty acyl-glycol)phosphate triester derivatives of 3'-fluoro-2',3'-dideoxythymidine Hitesh Kumar Agarwal, Gustavo F. Doncel, Keykavous Parang | ||
| 98 | Water-soluble prodrugs of lopinavir, ritonavir and new investigational HIV PIs David A. DeGoey, William J. Flosi, David J. Grampovnik, Kennan C. Marsh, Larry L. Klein, Michelle A. Long, Dale J. Kempf | ||
| 99 | Non-hydrolysable glycosylated porphyrins and chlorins: Potential new photodynamic therapy agents and applications in vivo imaging Sebastian A. Thompson, Diana Samaroo, Mikki Vinodu, Charles Michael Drain | ||
| 100 | Gd(III)-based bile acid conjugates for dual magnetic resonance and fluorescence imaging Sooyoun Lim, Xiang Ma, Hyun-Soon Chong | ||
| 101 | pH-Sensitive cyanine dyes for optical imaging of acidic environments Scott A. Hilderbrand, Ralph Weissleder | ||
| 102 | The preparation of the stable substrate for imaging HSV1-TK expression and its biological study gwangil An, kyochul Lee, Taehyun Choi, Hakjune Rhee, Hyunseok Ahn, Kwonsoo Chun, gijeong Cheon, sangmoo Lim, Byungseok Moon | ||
| 103 | Synthesis of novel technetium-99m-PIB complex as SPECT imaging agent for CNS disease Kuanqiang Gao, Chunying Wu, Yanming Wang | ||
| 104 | Peptide nucleic acid (PNA) FRET agents for imaging gene expression Bereket Y. Oquare, Huafeng Fang, John-Stephen Taylor | ||
| 105 | Decaprenyl diphosphate synthase inhibitors activate gamma delta T cells Fenglin Yin, Yonghui Zhang, Rong Cao, Craig T Morita, Eric Oldfield | ||
| 106 | Impact of secondary structure of agonists of Toll-like receptor 9 on immune stimulatory activity Dong Yu, Mallikarjuna R Putta, Lakshmi Bhagat, Daqing Wang, Meiru Dai, Jimmy X. Tang, Ekambar R. Kandimalla, Sudhir Agrawal | ||
| 107 | Synthetic agonists of Toll-like receptor 9: Impact of linkers Mallikarjuna R. Putta, Dong Yu, Daqing Wang, Lakshmi Bhagat, Meiru Dai, Jimmy X. Tang, Ekambar R. Kandimalla, Sudhir Agrawal | ||
| 108 | Synthetic oligoribonucleotides containing secondary structures activate Toll-like receptor 8 and induce immune responses Tao Lan, Lakshmi Bhagat, Meiru Dai, Jimmy X. Tang, Ekambar R. Kandimalla, Sudhir Agrawal | ||
| 109 | Synthesis and biological evaluation of NETA and NETA analogs as iron depletion agents Xiang Ma, Hyun-Soon Chong | ||
| 110 | Synthesis of a reactive linker for the construction of antibody-drug hybrid molecules Joshua D. Thomas, Thomas Hofer, Christoph Rader, Terrence R. Burke Jr. | ||
| 111 | Synthesis and use of cocaine-based MRI contrasting agents to detect the concentration of DAT Gregory R Naumiec, Brenton DeBoef | ||
| 112 | Noncovalent cellular delivery of phosphopeptides by amphipathic peptides Guofeng Ye, Nguyen H. Nam, Anil Kumar, Keykavous Parang | ||
| 113 | Bisphosphonates targeting geranylgeranyl diphosphate synthase: A QSAR investigation Rong Cao, Yonghui Zhang, Fenglin Yin, Michael P. Hudock, Eric Oldfield | ||
| 114 | Study of solvent interactions in solvolytic reactions of several common pharmaceutical intermediates Malcolm J. D'Souza, Zoon H. Ryu, Dennis N. Kevill, Byoung-Chun Park | ||
| 115 | Drug-receptor binding affinity: The strength of hydrophobic binding can be increased by adding hydrogen bonds Laveena Muley, Michael Smolinski, Bernhard Baum, Christof Gerlach, Marek Freindorf, Gerhard Klebe, David G. Hangauer | ||
| 116 | Hemostatic effects of liposomes carrying fibrinogen gamma-chain dodecapeptide and encapsulating adenosine 5'-diphosphate as a platelet substitute Yosuke Okamura, Ippei Maekawa, Makoto Handa, Yasuo Ikeda, Shinji Takeoka | ||
| 117 | From SAMs to drugs: Application of the Pharmacomer Technology Platform to small molecule drug discovery Bridget M Cole, Paul Sweetnam, Enoch Kim, David Duffy, James Ellis, Dominick Casalena, Alessandra Bartolozzi, Yingfei Yang, Hope Foudoulakis, Brian Kirk, Elsa Mak, Eric Wong, Sharon McGonigle, Stewart Campbell, Olivier Schueller, John Ferkany, William Prince | ||
| 118 | Conjugated porphyrin dimers with large two-photon absorption cross section for photodynamic therapy Milan Balaz, Hazel A. Collins, Marina K. Kuimova, Emma Dahlstedt, Klaus Suhling, David Phillips, Harry L. Anderson | ||
| 119 | Review of various classes of organic compounds for optimal purification on RediSep Rf Diol media Veronica D. Thomason | ||
| 120 | Examination of secondary conformational constraint in the design of macrocyclic Grb2-SH2 domain-binding ligands Fa Liu, Karen M. Worthy, Lakshman Bindu, Robert J Fisher, Terrence R. Burke Jr. | ||
| 121 | Synthetic efforts toward the development of Shc SH2 domain-binding peptides Won Jun Choi, Andrew G. Stephen, Robert J Fisher, Terrence R. Burke Jr. | ||
| 122 | Multimodal nanoagent for the diagnosis and treatment of atherosclerosis Jason R. McCarthy, Ethan Korngold, Farouc Jaffer, Ralph Weissleder | ||
| 123 | Paper Withdrawn | ||
| 124 | Anodized nanotubular titanium as novel drug eluting orthopedic implants Chang Yao, Thomas J. Webster | ||
| 125 | A structure- and NMR-based approach for the discovery of novel agents against Influenza A virus William H. Bisson, Maurizio Pellecchia | ||
| 126 | Inhibition of inducible nitric oxide synthase expression by structural analogs of pterostilbene Cassia S Mizuno, Shiby Paul, Nanjoo Suh, Agnes M. Rimando | ||
| 127 | Design and synthesis of novel cyclic oxyguanidines as potential iNOS inhibitors Guo-Hua Chu, Minghua Gu, Bertrand Le Bourdonnec, Christopher W. Ajello, Lara K. Leister, Joel A. Cassel, Robert N. DeHaven, Roland E. Dolle | ||
| 128 | Design and synthesis of novel imidazolepyrimidines as potent iNOS dimerization inhibitors - Part I Guo-Hua Chu, Bertrand Le Bourdonnec, Minghua Gu, Christopher W. Ajello, Lara K. Leister, Paul A. Tuthill, Ian Sellitto, Heather O'Hare, Joel A. Cassel, Robert N. DeHaven, Roland E. Dolle | ||
| 129 | Releasing of nitric oxide from elastic electrospun nanofibers Piyaporn Kampeerapappun, Marcos Lopez, Patricio Lopez-Jaramillo, Daniel J. Smith | ||
| 130 | Design and synthesis of novel imidazolepyrimidines as potent iNOS dimerization inhibitors Ian F Sellitto, Betrand LeBourdennec, Guo-Hua Chu, Minghua Gu, Christopher W. Ajello, Lara K. Leister, Paul A. Tuthill, Heather O'Hare, Joel A. Cassel, Robert N. DeHaven, Ronald E. Dolle | ||
| 131 | Potential applications of fendiline NONa in coronary health Melinda K. Carnahan, Wilmarie Flores, Daniel J. Smith | ||
| 132 | Synthesis, pharmacological and toxicological studies of nitric oxide releasing analog of acetaminophen Tilak Raj Bhardwaj, Manoj Kumar, Neeraj Mehta, Neelima Dhingra | ||
| 133 | Preclinical pharmacokinetic study of Zaltoprofen in rats Nageswararao Muddana, Gopinadh Bhyrapuneni, Koteshwara Mudigonda, Vishwottam N. Kandikere, Ramakrishna V. S. Nirogi | ||
| 134 | Discovery of orally active mGluR1 receptor antagonists for the treatment of chronic pain Stephanie Cooke, Peter Korakas, Lisa S. Silverman, Julius Matasi, Deen Tulshian, Duane Burnett, William J Greenlee, A. Reggiani, A. Veltri, R. Bertorelli, P Downey, S. Fredduzzi, M. Grilli, E. Nicolussi, G. Lozza, G Forlani, R Petrò, V Liporati, G. Tarozzo, S Contib, C. Foglia | ||
| 135 | The SAR and discovery of tricyclic mGluR1 antagonists for the treatment of chronic pain Julius Matasi, Stephanie Cooke, Peter Korakas, Lisa S. Silverman, Deen Tulshian, Duane A. Burnett, William J Greenlee, A. Reggiani, A. Veltri, R. Bertorelli, P Downey, S. Fredduzzi, M. Grilli, E. Nicolussi, G. Lozza, A Forlani, R Petrò, V Liporati, G. Tarozzo, S. Conti, C. Foglia | ||
| 136 | Discovery of piperidine carboxamide TRPV1 antagonists Raul R. Calvo, Wing S Cheung, Sui Po Zhang, Tasha Hutchinson, Mark R. Player | ||
| 137 | Pyrazolo-pyrimidines as selective and potent p38 inhibitors Robert V. Moquin, Jagabandhu Das, Gary Schieven, Sidney Pitt, Rosemary Zhang, Ding Ren Shen, Kim W McIntyre, Kathleen M Gillooly, Jack Sack, Arthur Doweyko, Hongjian Zhang, Susan E. Kiefer, Kevin Kish, Joel Barrish, John H. Dodd, Katerina Leftheris | ||
| 138 | Calcitonin gene-related peptide (CGRP) receptor antagonists: Development of the pyridinone series Diem N. Nguyen, Anthony W. Shaw, Daniel V. Paone, Christopher S. Burgey, Samuel L. Graham, Scott D. Mosser, Christopher A Salvatore, Yvonne M Leonard, Cynthia Miller-Stein, Stefanie A. Kane, Kenneth S. Koblan, Theresa M. Williams, Joseph P Vacca | ||
| 139 | Synthesis and biological evaluation of novel 5-(3-indolyl)-1-(4-sulfamylphenyl)-3-trifluoromethyl pyrazolines as dual inhibitors of COX/LOXs Vinaykumar Billa, Venkat R Pallela, Rengasamy Boominathan, Muralidhar R Mallireddigari, Balaiah Akula, Revathi Patti, Stanley C Bell, E. Premkumar Reddy, MV. Ramana Reddy | ||
| 140 | Syntheses and opioid receptor binding affinities of conformationally restricted analogs of Cyclazocine Rakesh R Ganorkar, Qun Lu, Mark P. Wentland, Jean M. Bidlack | ||
| 141 | Design, synthesis of a new chiral sigma-1 receptor ligand and validation as a potential anticocaine agent Marion Toussaint, Brice Delair, Catherine Foulon, Alexandre Lebeau, Nadège Lempereur, Claude Vaccher, Tangui Maurice, Patricia Melnyk | ||
| 142 | Tricyclic mluR1 antagonists for the treatment of chronic pain Chad Knutson, Chad Bennett, Peter Korakas, Duane A. Burnett, Deen Tulshian, William J Greenlee, A. Reggiani, Rosalia Bertorreli, M. Grilli, C. Foglia, S. Fredduzzi, G. Lozza, G. Tarozzo | ||
| 143 | Novel biaryl pyrazinone amides as hNav1.7 blockers for the treatment of neuropathic pain Feng Ye, Pengcheng Shao | ||
| 144 | Synthesis and structure-activity relationships of 3-substituted 8-benzhydryl-nortropane analogs as nociceptin receptor ligands Shu-Wei Yang, Deen Tulshian, Ginny D Ho, William J Greenlee, Stephen Eckel, John Anthes | ||
| 145 | Design of trisubstituted pyrimidines as vanilloid receptor 1 (TRPV1) antagonists with improved solubility Xianghong Wang, Partha Chakrabarti, Narender Gavva, Vassil I. Ognyanov, Liping H. Pettus, Rami Tamir, Helming Tan, Phi Tang, James JS. Treanor, Mark H. Norman | ||
| 146 | Synthesis of carbon-11 labeled benzoxazole derivatives as new potential PET radioligands for imaging of 5-HT3 receptor Mingzhang Gao, Min Wang, Qi-Huang Zheng | ||
| 147 | Synthesis of (S)-[18F]-fluoro-Exaprolol, via [18F]-1-fluoro-2-propanamine, for imaging cerebral beta-adrenergic receptors with PET Karin A. Stephenson, Erik M. van Oosten, Alan A. Wilson, Andrei K. Yudin, Jeffrey H. Meyer, Sylvain Houle, Neil Vasdev | ||
| 148 | Synthesis of carbon-11 labeled 7-aroyl-aminoindoline-1-sulfonamides as new potential PET agents for imaging cancer tubulin polymerization Min Wang, Mingzhang Gao, Qi-Huang Zheng | ||
| 149 | Synthesis of radiolabeled 2-oxoquinoline derivatives as new potential PET agents for imaging of CB2 receptor Mingzhang Gao, Min Wang, Qi-Huang Zheng | ||
| 150 | Discovery and biological evaluation of novel 2-acetamido-indoles as potent and selective openers of Kv7/KCNQ potassium channels Thomas E Christos, Grant McNaughton-Smith, Robert N. Atkinson, Matthew E. Secrest, Aaron C. Gerlach, Scott D. Conary, Brett M. Antonio, Sally J. Stoehr, Rosemarie Roeloffs | ||
| 151 | Classifcation QSAR modeling of the imbalanced dataset of hERG K+ channel blockers and openers Kun Wang, Alexander Golbraikh, Bryan R. Roth, Alexander Tropsha | ||
| 152 | Synthesis and SAR of thiadiazolone dioxides as selective androgen receptor modulators Mark Manfredi, Yingzhi Bi, Alexandra Nirschl, James Sutton, Ramakrishna Seethala, Rajasree Golla, Blake Beehler, Paul Sleph, Gary Grover, Jacek Ostrowski, Lawrence Hamann | ||
| 153 | Design of potent and selective LXR agonists from a series of indazole aniline core compounds Stephen Marc Bowen, Robert J. Steffan, Edward Matelan, Raymond Unwalla, Ponnal Nambi, Elaine Quinet, Anita Halpern, Dawn Savio, Anna Wilhelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Tomas Bonn, Mathias Farnegardh, Jay Wrobel | ||
| 154 | Quinoline biarylethers as high affinity, potent LXR agonists Ronald C. Bernotas, Robert R. Singhaus Jr., David Kaufman, John W. Ullrich, Robert L. Morris, Horace Fletcher III, Li Di, Ray J Unwalla, Ponnal Nambi, Elaine Quinet, Dawn Savio, Anita Halpern, Irene B. Feingold, Anna Wihelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Jay Wrobel | ||
| 155 | Quinoline biarylether amides as liver X receptor modulators David Kaufman, Ronald C. Bernotas, Robert R. Singhaus Jr., Michael Collini, John W. Ullrich, Ray J Unwalla, Li Di, Ponnal Nambi, Elaine Quinet, Anita Halpern, Dawn Savio, Irene Feingold, Anna Wihelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Jay Wrobel | ||
| 156 | Discovery and structure-activity relationship studies of indole derivatives as Liver X receptor (LXR) agonists Madhavi Pannala, Farid Bakir, Sunil Kher, Norma Wilson, Trang Nguyen, Ila Sircar, Kei Takedomi, Chiaki Fukushima, James Zapf, Kui Xu, Shao-Hui Zhang, Juping Liu, Morera Lisa, Lisa Schneider, Naoki Sakurai, Rick Jack, Jie-Fei Cheng | ||
| 157 | Synthesis, hypolipidemic activity and computational studies of phenoxyacetic acid derivatives related to α-asarone and clofibrate Nancy Argüelles, José Luis Medina-Franco, Aaron Mendieta, Fabiola Jiménez, Leticia Garduño, Maria del Carmen Cruz, Germán Chamorro, Joaquín Tamariz | ||
| 158 | Identification of highly potent and subtype-selective PPARalpha agonists: Synthesis, SAR and in vivo efficacy Yukiyoshi Yamazaki, Kazutoyo Abe, Tsutomu Tohma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Soichi Oda, Keisuke Inoue, Kimiyuki Shibuya, Bart Staels, Jean-Charles Fruchart | ||
| 159 | Design, synthesis and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent PPARalpha/gamma dual activators Xiang-Yang Ye, Yi-Xin Li, Shung Wu, Arthur Doweyko, Dennis Farrelly, Neil Flynn, Liqun Gu, Kenneth T. Locke, Jonathan Lippy, Kevin O'Malley, Celeste Twamley, Litao Zhang, Denis E. Ryono, Narayanan Hariharan, Robert Zahler, Peter T. W. Cheng | ||
| 160 | Discovery and structure-activity relationships of BMS-711939, a potent and highly selective PPARalpha activator Yan Shi, Jun Li, Lawrence J. Kennedy, Hiwei Tao, Xiang-Yang Ye, Stephanine Chen, Hao Zhang, Andres Hernandez, Sean Chen, Zhi Lai, Wei Wang, Pratik Devasthale, Rebecca Smirk, Shung Wu, Scott A. Bolton, Denis Ryono, Ying Wang, Kenneth T Locke, Kevin M. O'Malley, Litao Zhang, Raiajit Srivastava, Bowman Miao, Daniel Meyers, Hossain Monshizadegan, Debra Search, Denise Grimm, Rongan Zhang, Thomas Harrity, Lori Kunselman, Henry Wong, Juliang Zhu, Ashok Trehan, Ngiap-Kie Lim, Huiping Zhang, Bang-Chi Chen, Michael Cap, Jodi Muckelbauer, Chiehying Chang, Stanley Krystek, Yi-Xin Li, Vinayak Hosagrahara, Lisa Zhang, Pathanjali Kadiyala, Carrie Xu, Michael Blanar, Robert Zahler, Ranjan Mukherjee, Peter T. Cheng, Joseph A. Tino | ||
| 161 | Novel zwitterionic phenoxyacetic acid derivatives as potent PPAR agonist Mitsuhiro Yamaguchi, Yoshihiro Shibata, Masahiro Ohta, Katsuji Kagechika, Hiroyuki Usui, Toshiharu Ohta | ||
| 162 | Structure activity relationship studies of phenethylglycine PPARa/g dual activators for the treatment of metabolic diseases Shung Wu, Rebecca Smirk, Hao Zhang, Sean Chen, Dennis Farrelly, Liqun Gu, Andrew Peters, Thomas Harrity, Michael Cap, C Chu, Lori Kunselman, Nathan Morgan, Randolph Ponticiello, Rachel Zebo, Litao Zhang, Kenneth T Locke, Jonathan Lippy, Kevin M. O'Malley, Vinayak Hosagrahara, Lisa Zhang, Pathanjali Kadiyala, Carrie Xu, Arthur Doweyko, Jodi Muckelbauer, Robert Zahler, Narayanan Hariharan, Peter T. Cheng | ||
| 163 | Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPAR delta agonists Rui Zhang, Aihua Wang, Alan DeAngelis, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo | ||
| 164 | Novel bisphosphonates targeting prenyltransferases Yonghui Zhang, Fenglin Yin, Rong Cao, Michael P Hudock, Kilannin Krysiak, Annette Leon, Craig T Morita, Eric Oldfield | ||
| 165 | Design, synthesis, and biological evaluation of 17-thiazole-4-azasteroids as tissue-selective androgen receptor modulators Mildred L. Kaufman, Helen J. Mitchell, George D. Hartman, Thomayant Prueksaritanont, Azriel Schmidt, Chang Bai, Fang Chen, Donald B. Kimmel, Mark E. Duggan, Robert S. Meissner | ||
| 166 | Synthesis, structure-activity relationship, in vitro/in vivo profiles and molecular modeling of novel oxa-steroids as potent and selective progesterone receptor antagonists Fu-An Kang, Jihua Guan, Nareshkumar Jain, George Allan, Olivia Linton, Pamela Tannenbaum, Jun Xu, Peifang Zhu, Joseph W Gunnet, Xin Chen, Keith Demarest, Scott Lundeen, Zhihua Sui | ||
| 167 | Preparation of diverse array of imidazoles for general screening David J. Malwitz, Pawel Nowak | ||
| 168 | Rapid SAR against functional Cardiac Ion Channels using an automated patch clamp system Nathan J Lautermilch, Adam Bishop, Teddy Lin, Shimin Wang, James Baumgartner | ||
| 169 | Selection of compounds in discovery stage based on the novel HTS solubility measurement and parallel artificial membrane permeability assay Katsuya Akimoto, Kyosuke Suzuki, Shinsaku Tsukamoto, Kenichi Sudo, Osamu Okazaki | ||
| 170 | Design and synthesis of site-selective fluorescent naphthalimide probes for microscopy Leah L. Groess, Ashley M. Dreis, Kyle M. Kopidlansky, David E. Lewis | ||
| 171 | Microarray screening of antithrombin interactions on the high affinity heparin glycan chips Tae-Joon Park, Moo-Yeal Lee, Moon Il Kim, Jeffrey G. Martin, Jonathan S. Dordick, Robert J. Linhardt | ||
| 172 | Studies on the ligand selectivity and economics of metal scavenging polymers Paul A Boguszewski, Andrew F Coffey, Aubrey J Mendonca, John W Davies, Frank P Warner | ||
| 173 | New techniques for salt and polymorph screening of new drug candidates Carl H Behrens, Hui-Yin Harry Li | ||
| 174 | Open access mass-directed purification: Adaptation to diverse loading scales and compound polarities Leonard O Hargiss, Weiqun Wang | ||
| 175 | NCI60 screening data: A versatile tool for in silico models predicting substrate properties for ABC-transporter Gerhard F Ecker, Barbara Zdrazil, Chakguy Prakasvudhisarn | ||
| 176 | Virtual screening of the inhibitors into Tyrosyl-DNA Phoshodiesterase (Tdp1) active sites Iwona E Weidlich, Thomas Dexheimer, Yves Pommier, Christophe Merchand, Marc C Nicklaus | ||
| 177 | Molecular docking and 3-D-QSAR studies on a series of 6,7-dimethoxy-4-pyrrolidylquinazoline as PDE10A inhibitors Shridhar Kulkarni, Tanaji T Talele | ||
| 178 | Predicting modifications to the inhibitor of InhA, the M.tb enoyl reductase enzyme to stabilize inhibitor-active site loop interactions using computational chemistry tools Salma Banu Rafi, Peter J. Tonge, Carlos L. Simmerling | ||
| 179 | Chemical modifications to improve pharmacokinetic properties of siRNA: Probing the tolerance of phosphorothioate modifications on siRNA activity Thazha P. Prakash, Garth A. Kinberger, Charles R. Allerson, Andrew T. Watt, Andreas Berdeja, Hans J. Gaus, Eric G. Marcusson, Eric E. Swayze, Balkrishen Bhat | ||
| 180 | Polyconjugates: A new synthetic vehicle for in vivo delivery of siRNA to hepatocytes Darren H. Wakefield, David Rozema, So C. Wong, Jason J. Klein, Dave L. Lewis, Stepanie Bertin, Tom Reppen, Paula L. Roesch, James E. Hagstrom, Jon A. Wolff | ||
| 181 | Studies toward the synthesis of fluorescent and isotopically labeled discodermolide analogs Chao Yang, Abhijit Banerjee, Susan Bane, David G. I. Kingston | ||
| 182 | Stereoselective total synthesis of soybean flavonoids Glyceollin I, II Rahul S Khupse, Paul W Erhardt | ||
| 183 | Stereoselective synthesis of (2S,3S,4S)-3,4-dihydroxy-L-glutamic acid via intramolecular nucleophilic epoxidation Young Gyu Kim, Hyeonjeong Kim, Dongwon Yoo, Myeong Hak Kim, Suk-Koo Hong | ||
| 184 | Improved asymmetric synthesis of the alose reductase inhibitor 2-methyl sorbinil Hongxia Jin, James M. Randazzo, Peter F. Kador | ||
| 185 | Study for total synthesis of antibiotic pestalone and its analog Yudao Ma, Yong Dai, Zhijun Sun, Xi Fang, Changqin Ma, Chun Song | ||
| 186 | An efficient and operationally convenient general synthesis of tertiary amines by direct N-alkylation of secondary amines and heterocycles with alkyl halides in the presence of CsOH Ralph Nicholas Salvatore, Jason Hovland | ||
| 187 | Synthesis of fluorine-containing heterocycles for medicinal chemistry Mark J. Penny, Adrian P Dobbs, Levan Pivnevi, Peter Jones | ||
| 188 | Synthesis of novel fluorinated carbohydrate and pipecolic acid analogs and C-aryl glycosides via a common methodology Adrian P Dobbs, Diluar Khan, Robert J Parker | ||
| 189 | Applications of polymeric reagents and SPE in the synthesis and purification of reductive amination reactions Paul A Boguszewski, Andrew F Coffey, John W Davies, Aubrey J Mendonca, Frank P Warner | ||
| 190 | Selective N-alkylation of aromatic amines Ralph N. Salvatore, Jason Hovland | ||
| 191 | Synthesis of N-9-substituted 2,8-diaminopurines Gulzar Ahmed, Andrew G. Cole, Marc-Raleigh Brescia, Ian Henderson, Lan-Ying Qin, Axel Metzger, James Wen, Ray J. Chan, Linda O'Brien | ||
| 192 | From a polymer crosslinker to soluble epoxide hydrolase (sEH) inhibitors: The quest for lower cost drug intermediates James R. Sanborn, Christophe Morisseau, Paul D. Jones, Hsing-Ju Tsai, Sung Hee Hwang, Bruce D. Hammock | ||
| 193 | Production of different structural analogs of sophorolipids through modification of fermentation medium Vishal Shah, Dan Badia | ||
| 194 | Versatile photosensitizers based on photon upconverting nanoparticles for photodynamic therapy Peng Zhang, Wim Steelant, Manoj Kumar, Matthew Scholfield | ||
| 195 | Allosteric modulation of mGluR1 and mGluR5 Tanja Weil, Gisbert Schneider, Steffen Renner, Swetlana Derksen, Mirko Hechenberger, Christopher G. Parsons | ||
| 196 | Benzamide inhibitors of soluble epoxide hydrolase Steven J Taylor, Stéphane DeLombaert, Anne Eldrup, Neil Farrow, Ingo Mugge, Fariba Soleymanzadeh | ||
| 197 | Paper Withdrawn | ||
| 198 | In vitro metabolic studies of a bivalent KOR agonist, MOR mixed agonist Brian S. Fulton, Jennifer L. Mathews, Jean M. Bidlack, John L. Neumeyer | ||
| 199 | Paper Withdrawn | ||
| 200 | Paclitaxel (Taxol®) binding to human serum albumin: Insights from computational studies Krisztina Paal, Aliaksei Shkarupin, Laura Beckford | ||
| 201 | Paper Withdrawn | ||
| 202 | Structural dynamics of the cooperative binding of organic molecules in the human Cytochrome P450 3A4 (CYP3A4) Dan Fishelovitch, Carina Hazan, Sason Shaik, Haim Wolfson, Ruth Nussinov | ||
| 203 | High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis Todd J. Sullivan, Christopher am Ende, James J. Truglio, Francis Johnson, Ann Lenaerts, Richard A. Slayden, Caroline Kisker, Peter J Tonge | ||
| 204 | Structure-based design, synthesis, and biological evaluation of novel inhibitors of Mycobacterium tuberculosis malate synthase Justin P. Roberts, Inna Kriger, Qingan Sun, Eric McKee, Thomas R. Ioerger, Joel S. Freundlich, James C. Sacchettini | ||
| 205 | Synthesis and optimization of a library of novel benzimidazole leads for antituberculosis drug discovery Kunal Kumar, Seung-Yub Lee, Ilaria Zanardi, Richard A. Slayden, Iwao Ojima | ||
| 206 | Synthesis of novel optically active 2-aminobenzothiazole derivatives as antitubercular agents Bhoomendra A. Bhongade, Malleshappa N. Noolvi, Andanappa K. Gadad, Gurdial Singh | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 234th ACS National Meeting, Boston, MA, August 19-23, 2007