BIOTTuesday, August 21, 2007

8:00 AM-11:05 AM BCEC -- 106, Oral
Biophysical and Biomolecular Symposium: Protein Chemical Instability
Organizers:Elizabeth M. Topp
Mary Cromwell
8:00 AMIntroductory Remarks
8:05 AMChemical stability of proteins in injectable drug delivery systems
Franklin Okumu
8:25 AMFragmentation within human IgG1 hinge region: Two distinct mechanisms, two different outcomes
Josef Vlasak, Colleen E. Price, Steven L. Cohen
8:45 AMGamma irradiation-induced damage in proteins and peptides
Sheng-Xue Xie, Todd D. Williams, Dru Willey, Elizabeth M. Topp
9:05 AMImpact of degradations on bioactivity: A reflection from a monoclonal antibody
Bryan L Yu, Alona Vizel, Meagan Young, Ashley Morando, Bing He
9:25 AMIntermission
9:45 AMSelective protein oxidation through reactive oxygen species: Catalysis by cysteine
Christian Schoneich
10:05 AMUsing solution NMR to probe the effects of excipients on protein stability
Jennifer S. Laurence
10:25 AMEffect of residual moisture content on the stability of dried Apo2L/TRAIL crystals
Heather Flores, Ana Sofia Ressurreiçao, Boyan Zhang, Bruce Kabakoff, Zahra Shahrokh, Mary E. M. Cromwell
10:45 AMProtein stability at solid substrates: Influence of chemical and thermal excursions
Gaurav Anand, Georges Belfort

Symposium Grid -- Division of Biochemical Technology -- Session Listing

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007