CARB 37 |
| RNA interference (RNAi) is a powerful biological process for specific silencing of mRNAs in diversified eukaryotic cells. The technique has tremendous potential for use in functional genomics, for drug discovery through in vivo target validation, and for development of novel gene-specific medicine for virtually any disease target, including the so-called ‘non-druggable' targets. A related RNA interference process involves modulation of microRNAs to control gene expression. A critical requirement for achieving safe and efficacious RNAi therapy is introduction of “drug-like” properties, such as specificity, stability, cellular delivery, and tissue biodistribution, into synthetic siRNAs to improve in vivo pharmacological properties. Our presentation will review the role of the chemist's toolbox in this emerging technology. |
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RNA Interference Based Therapeutics
8:30 AM-11:50 AM, Tuesday, August 21, 2007 BCEC -- 208, Oral
Division of Carbohydrate Chemistry |