BIOL 161 |
| Isoprenoids are one of the largest and most structurally diverse groups of metabolites in nature. All isoprenoids are derived from isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP). There are two different pathway for IPP and DMAPP biosynthesis, the MVA pathway in eukaryotes and DXP pathway in prokaryotes. In the DXP pathway, both IPP and DMAPP are synthesized form 1-hydroxy-2-methyl-butenyl 4-diphosphate (HMBPP) catalyzed by IspH (LytB) enzyme. Recently, it was proposed by Rohdich et al. that IspH catalyzed reaction follows a biological counterpart of the Birch reduction of allylic alcohols with lithium in liquid ammonia. In this study, substrate analogs are designed to evaluate the proposed mechanism and our recent results will be presented. |
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Frontiers in Chemical Biology
5:00 PM-7:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biological Chemistry |