Synthesis of and mechanisms of DNA damage by 3-cyclopropyl-1,2,4-benzotriazine 1,4-dioxide

TOXI 42

Ujjal Sarkar, usn66@mizzou.edu, Department of Chemistry, University of Missouri, 125 Chemistry, Columbia, MO 65211 and Kent S. Gates, GatesK@missouri.edu, Departments of Chemistry and Biochemistry, University of Missouri - Columbia, 601 S. College Ave., Columbia, MO 65211.
1,2,4-Benzotriazine 1,4-dioxides are potent antitumor drug candidates that undergo in vivo bioreduction leading to selective DNA damage in the low oxygen (hypoxic) cells found in tumors. We prepared a cyclopropyl derivative as tool for probing the mechanisms of DNA damage by this class of drugs. Here we will report on the mechanisms of enzyme-activated DNA damage by 3-cyclopropyl-1,2,4-benzotriazine 1,4-dioxide and relate our findings to the medicinal action of this clinically promising class of compounds.

 

Poster Session and Awards
6:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- 204 A/B, Poster

Division of Chemical Toxicology

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007