ORGN 483 |
| As a potential green and efficient process to construct complicated structures from simple and commercial available chemicals, C-H bonds may be functionalized to construct C-C, C-N and C-X bond via Pd-catalyzation.1 We have already reported ortho halogenation with acetamino group as a directing group.2 According to this observation, we further developed remarkable transformations to realize ortho arylation of acetanilides via Pd(II)-catalyzed direct C-H functionalization with aryl silanes and aryl boronic acids. Besides providing a unique way to prepare ortho aryl substituted acetanilides through direct C-H activation, the study has also indicated that C-H bond could be applied for the coupling as a partner under mild condition in general to offer an environmentally friendly way to construct C-C bond.
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Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
