ORGN 123 |
| The utility of intra- and intermolecular olefin metathesis in total synthesis has been well established. Herein we present (1) tandem cross-metathesis/Wittig or Horner-Wadsworth-Emmons olefination methodology for the stereoselective synthesis of both (2E,4E)- and (2Z,4E)-dienoates; and (2) an efficient strategy for natural product synthesis which sequences allyl- or crotylmetallation reactions with olefin cross metathesis. Application of the latter towards a concise total synthesis of (+)-crocacin C will be discussed.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
