CARB 54 |
| In order to improve the pharmacokinetic properties of siRNAs, which are intrinsically poor binders to serum proteins and rapidly cleared through the renal system, we conjugated Apo-B siRNAs to polyethylene glycol (PEG) using a hydroxyprolinol linker. In contrast to the corresponding cholesterol conjugates, PEG-siRNA gene silencing was observed in the jejunum and not in the liver. Furthermore, the observed effect was dependent on the length of the PEG used. Synthesis of the conjugates, analytical characterization, and in vivo pharmacology will be presented. |
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General Posters
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Carbohydrate Chemistry |