Total syntheses of (+)-Lyconadin A and (-)-Lyconadin B

ORGN 338

Amos B. Smith, smithab@sas.upenn.edu and Douglas C. Beshore. Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center, University of Pennsylvania, Philadelphia, PA 19104
The enantioselective syntheses of (+)-Lyconadin A and (-)-Lyconadin B will be presented. Key bond constructions include a strategy-level intramolecular aldol reaction-conjugate addition cascade, an olefin aminoiodination and a novel one pot α-pyridinone annulation.

 

Peptide Natural Products
1:00 PM-4:50 PM, Monday, August 20, 2007 BCEC -- 253 A/B/C, Oral

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007