Building proteins with new therapeutic functions from peptide modules

BIOT 207

Patrick S. Daugherty, Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106
We have developed a family of new molecular diversity tools for the discovery and optimization of peptides with improved functions. Modular peptide components designed for cell-specific targeting, enzymatic activation, membrane penetration, and highly-specific protein inhibition can be assembled piecewise to build multifunctional proteins.Collectively, these and related methodologies create exciting new opportunities for the design and engineering next generation biopharmaceuticals.