ANYL 368 |
| SFC columns from 3 cm inner diameter to production scale require designs that correlate to CE and/or ASME safety guidelines. Thus, preparative SFC columns should have a thicker wall and more robust closures to meet these guidelines. Furthermore, every state has a boiler code that regulates the use of high pressure gases in vessels and CO2 in a supercritical state falls in this category. In the talk, we will show that all SFC columns are not alike and that some columns are better packed than others. Finally, we will attempt to find out if chiral stationary phases with 5 micron particles are really necessary in preparative SFC vs. 20 micron particles at 1/3 of the price. This price/performance data will help a scientist select the best columns and stationary phases while adhering to high safety standards in the US and Europe. |
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Fast Preparative Chromatography in Pharmaceutical Drug Discovery
1:30 PM-4:50 PM, Tuesday, August 21, 2007 BCEC -- 105, Oral
Division of Analytical Chemistry |