ANYL 37 |
| A fast, simple, robust UPLC/MS/MS method has been developed for the analysis and confirmation of 52 pesticides in various baby food matrices. Chromatographic separation was achieved using a 1.7µm particle size column (50 mm length) with a total cycle time of less than 10 minutes. Polarity switching during MS acquisition allowed the determination of 44 compounds which ionize in positive ion mode and 8 which ionize in negative ion mode during a single chromatographic run. Two MRM transitions were monitored for each compound. The primary transition was used for quantification and the secondary transition used for confirmation purposes. The use of very short dwell times of 5 ms was found to have no effect on signal intensity, indicating that sensitivity can be maintained while monitoring over 100 MRM transitions during a single run. Method robustness was proven with a 100 injection sequence, delivering over 200 mg of matrix to the instrument. |
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Tandem LC-MS and GC-MS
1:30 PM-4:40 PM, Sunday, August 19, 2007 BCEC -- 104A, Oral
Division of Analytical Chemistry |