BIOL 111 |
| Group II introns are large, multifunctional ribozymes that can catalyze a diversity of reactions, including self-splicing, the invasion and targeting of duplex DNA, and the insertion of new genes. They are being developed as biotechnological tools and they are of great interest as models for catalysis by complex RNA active-sites. They have an elaborate tertiary architecture that we have studied through biophysical and biochemical techniques. The dynamic architecture of group II introns is yielding new insights into novel RNA tertiary interaction motifs, folding pathways, and conformational dynamics. Through structural and functional analysis of group II intron structure, we are learning about the formation of multidomain RNA architecture and the molecular evolution of RNA processing machinery. |
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Murray Goodman Award Symposium
2:00 PM-4:40 PM, Monday, August 20, 2007 BCEC -- 109 A/B, Oral
Division of Biological Chemistry |