Some applications of GC-MS/MS and LC-MS/MS to analyze pesticides and chemical contaminants in foods

ANYL 38

Jon W. Wong, jon.wong@fda.hhs.gov, Office of Regulatory Science, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-706, College Park, MD 20740-3835 and Alexander J. Krynitsky, Alex.Krynitsky@cfsan.fda.gov, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835.
Traditionally, many of the pesticide and chemical contaminant screening in foods at the FDA have been analyzed by gas chromatography (GC) with element specific detectors, liquid chromatography (LC) with non mass spectrometry detectors, and GC-mass spectrometry using selected ion monitoring (GC-MS/SIM) procedures. Currently we are applying GC-tandem mass spectrometry (MS/MS) and LC-MS/MS with triple quadrupole analyzers (QqQ) to provide improved detection and identification. Some recent examples where LC-MS/MS has been successfully used include the analysis of acrylamide and perchlorate in a variety of food samples. Interlaboratory comparisons and comparisons between ion chromatography (IC) and IC-MS/MS have been successfully performed for the analysis of perchlorate in fresh produce, dried food products, milk and bottled water. We are currently adopting GC-MS/MS and LC-MS/MS methods for the analysis of pesticides in fresh and non-fatty produce and in dried botanical dietary supplements. We were able to identify pesticides, using GC-MS/MS, in incurred produce samples in cases when GC-MS/SIM was ineffective due to matrix interferences. The advantages and disadvantages of GC and LC (non-MS detection systems) with GC-MS/MS and LC-MS/MS procedures will be addressed to specific food analysis conducted at FDA/CFSAN.
 

Tandem LC-MS and GC-MS
1:30 PM-4:40 PM, Sunday, August 19, 2007 BCEC -- 104A, Oral

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007