A) Using molecules to build molecules; B) Active transport of organic cations through fluorous bulk membranes by nanohosts

AEI 86

Qianli Chu, chu001@pitt.edu1, Leonard R. MacGillivray2, and Dennis P. Curran1. (1) Department of Chemistry, University of Pittsburgh, Chevron Science Center, 219 Parkman Avenue, Pittsburgh, PA 15260, (2) Department of Chemistry, University of Iowa
A) Template-directed synthesis enables chemists to preorganize molecules to react and form single or multiple covalent bonds. This approach of juxtaposing molecules to react could have widespread applications in chemical synthesis and materials science. With these concepts in mind, both wet-lab experiments and computational studies have been employed to illustrate the power of this method, as well as its applications.

B) Fluorous solvents, which are both hydrophobic and lipophobic, could be ideal bulk membranes for both (in)organic ions and molecules. Fluorous resorcinarenes are synthetic hosts for cations (e.g. tetramethylammonium ion) and their complexes could only be dissolved in the fluorous phase. Deprotonation of resorcinarenes at the interface with a basic source phase and protonation of its complex at the interface with an acidic receiving phase offers a driving force for transport.

 

Academic Employment Initiative
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Academic Employment Initiative

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007