A natural products research program for implementation at a primarily undergraduate institution

AEI 96

Katherine N Maloney, knmaloney@ucsd.edu, Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, 9500 Gilman Drive, La Jolla, CA 92093-0204, William Fenical, wfenical@ucsd.edu, Center for Marine Biotechnology and Biomedicine, Univ Calif San Diego, Scripps Institution of Oceanography, La Jolla, CA 92093-0204, and Jon Clardy, jon_clardy@hms.harvard.edu, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115.
Actinomycetes isolated from ocean sediments represent an untapped source of biological and chemical diversity. The isolation of cancer chemopreventive agents from these bacteria will be described. Plants and the fungi that colonize them (endophytic fungi) are also prolific producers of structurally interesting and potently bioactive small molecules. The isolation of natural products from Costa Rican endophytic fungi and traditional Chinese medicinal plants which showed unique biological activities in a variety of screens at Harvard Medical School will be described. Lastly, a natural products research program will be presented with the objective of obtaining a position at a primarily undergraduate institution.