AEI 12 |
| My teaching and research interests are aimed at understanding structure-function relationship of protein complexes employing data primarily obtained from small angle x-ray/neutron scattering (SAXS/SANS). Using relatively small sample volumes, one can reliably decipher global structural changes in biomolecules by SAXS-data analysis and ab initio structure reconstruction. Currently, we focus on protein systems with high biological relevance but lacking key structural insights from crystallography or NMR or EM. Novelty and prowess of this approach, in solving challenging biophysical problems, is evident from our results addressing large scale shape changes accompanying Ca2+-activation of gelsolin, and binding of HIV-1 gp120 to its receptor CD4. To decipher shape profiles of individual components while they reside in a complex, we combine the differences in the SANS properties of hydrogen and deuterium with the constitutional contrast in hydrogen content of a protein and its ligand.
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Academic Employment Initiative
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix
Academic Employment Initiative |
