Characterization of novel salicylate drug trees via various analytical techniques

ANYL 80

Nichole K. Nevorski, minghui.chai@cmich.edu1, Zhiyuan Wang2, Stephen M. June, june1sm@cmich.edu1, Shengzhuang Tang1, Bob A. Howell1, and Minghui Chai, minghui.chai@cmich.edu1. (1) Department of Chemistry, Central Michigan University, Mt. Pleasant, MI 48859, (2) Mount Pleasant High School, Mount Pleasant, MI
In this presentation, NMR spectroscopy including multidimensional NMR and diffusion NMR techniques was used to characterize a new class of dendrimers synthesized using biocompatible building blocks: succinic acid, glycerol and salicylic acid, through biodegradable ester linkages. GPC, MALDI-TOF-MS and UV-Vis analyses were also performed on these dendrimers. Unlike drug-dendrimer conjugation and encapsulation, these novel dendrimers are built up with salicylic acid entities in a cascade distribution from the core to the exterior. Thus the dendrimers themselves are intrinsic drugs or prodrugs, which are vividly named as drug-trees. The results from the analyses clearly indicated that the synthesized dendrimers have high purity and expected structures.
 

General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007