AGRO 146 |
| The deterioration effects of aluminum chloride AlCl3 medium dose (30 mg/kg body weight/day) short-term (40 days) in drinking water were studied on experimental rat brain, serum, bones and kidneys. Vitamin C as reducing agent was given orally to detect the effect of antioxidants to protect rat from suppressing caused by aluminum-stress in drinking water. Vitamin C was used as commercial chemical, pharmacological drug and aqueous balady orange peel extract in the same vitamin concentration (1.4 g/l). Comparing to negative untreated rat, Al in drinking water (positive control) significantly decreased daily body weight gain, daily feed intake and food efficiency. Causing neurotoxic effect and oxidative damage, Al increased serum cholinesterase ChE insignificantly, brain ChE significantly and lipid peroxidation LP significantly as well. Al showed significant decreased of serum vitamin C content. Serum lipid profile and kidneys profile have been studied. Neurodegenerative changes have been noticed as neurotic plaques and necrosis in the cerebellum. Comparison study between different vitamin sources; (commercial, medical and natural extracted) effects on deterioration effect of Al has been done. Comparing to positive control, vitamin C sources showed significant increase for food efficiency. Extracted vitamin insignificantly reduced serum ChE activity and improved HDL, and LDL values, insignificantly. While, medical vitamin showed significant decrease of brain ChE, improved kidney function significantly and increased serum Ca insignificantly. Apparent and normal histopathological changes have been detected especially with sections of natural vitamin extract. |
|
New Developments and Issues in Agrochemical Sciences
8:45 AM-11:50 AM, Thursday, August 23, 2007 BCEC -- 259A, Oral
Division of Agrochemicals |