AGRO 124 |
| Triazole containing compounds are used extensively in both agriculture and medicine for the control of fungal infections. Recently emphasis has been placed on the potential adverse effects of these compounds within mammalian systems. Triadimefon is a common agricultural fungicide. It contains one chiral center, and forms a second chiral center when metabolized to triadimenol, another commercially used fungicide. We have studied the enantioselective metabolism of the individual enantiomers and racemate of triadimefon to triadimenol in microsomes from various male and female mammals, fish and invertebrates. In all species and genders, (+) triadimefon was metabolized more quickly than (-) with the enantiomeric fractions of the resulting four triadimenol enantiomers being species specific. Inhibitor and pure enzyme studies indicate that triadimefon is metabolized by a short-chain dehydrogenase/reductase and may disrupt steroid pathways. These finding will be put in context of species differences, potential impacts on steroidogenesis and tumorgenesis, and risk assessment. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
|
|
Modern Chiral Agrochemicals
8:30 AM-12:15 PM, Wednesday, August 22, 2007 BCEC -- 259B, Oral
Division of Agrochemicals |