AGRO 60 |
| Oxidation of alpha synuclein was found to be influential to the protein aggregation which is the hallmark of Parkinson's disease. Methionine and tyrosine are the two possible candidates causing the oxidation in the sequence of alpha synuclein. Binding of oxygen or nitrogen will change the hydrophobicity of alpha synuclein, affecting the fibrillation process. Antioxidants in diets and Chinese medicines, especially the compounds in natural plants, are playing role in decreasing the reactive oxidation species in neural system. By employing cyclic voltammetry in a physiological medium, authors have observed the electrochemical process of alpha synuclein oxidation at an electrode surface. Four antioxidant compounds rich in natural plant extracts are tested in interacting with the alpha synuclein molecules. Formation of nanoscale oligomers are tracked by a time lapse manner. An Oxidation following coordination mechanism was proposed for the interaction of alpha synuclein with antioxidants and participating metals and the formation of the nano-bioparticles. **We acknowledge the supports of NC-LSAMP Program, MBRS-RISE program at Fayetteville State Univeristy and the Grant P20 MD001089-02 from the National Institution of Health, NCMHD, and Department of Health and Human Services. |
|
New Developments and Issues in Agrochemical Sciences
8:00 AM-11:00 AM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Agrochemicals |