5-Thioalkyl-1,3,4-thiadiazole-2-carboxylic acid derivatives as nematicides

AGRO 68

Wenming Zhang, Wenming.Zhang@usa.dupont.com and Yvonne Bethel. Stine-Haskell Research Center, Dupont Crop Protection, 1090 Elkton Road, Newark, DE 19711-3507
5-Thioalkyl-1,3,4-thiadiazole-2-carboxylic acid derivatives have been shown to possess high nematicidal activity. To optimize the nematicidal activity and maintain the required physical properties, we were drawn to prepared different acid derivatives and replace the 1,3,4-thiadiazole ring with various other 5-membered, 6-membered heterocycles. This poster will outline the synthetic approaches we used to make the desired compounds as well as their biological activity.