ANYL 148 |
| Bioanalysis of pharmacokinetic screening studies is seen as a bottleneck in delivering new drug candidates to the clinic. To address this issue, analysts use generic methods, automation and shorter run times as solutions. However, there are concerns of method ruggedness and suppression from matrix and formulation when using shorter runs. mPLC may resolve those issues, but that requires the purchase of expensive equipment. Another option is to use a column with a fused core, like the Halo™ column, which allows high-speed analysis with high column efficiency. This presentation will evaluate the use of the Halo ™ C18 4.6x30 mm, 2.7u column for the routine analysis of structurally diverse, discovery compounds dosed in pharmacokinetic screening studies. Data will be presented and discussed showing a 30% reduction of bioanalytical run time. The impact of this reduction is allowing multiple runs on existing equipment, and a faster turn around of data to project teams. |
|
General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |