MEDI 207 |
| A major unfilled need in the medical community is effective medication for treatment of drug addiction. This talk will initially briefly review our understanding of the brain mechanisms involved in drug addiction from neurochemical, genetic and brain imaging perspectives. Afterwards, a review of animal models useful for testing potential medications will be presented together with data showing efficacy of various classes of agents in preclinical tests: long acting DAT blockers, D3 receptor antagonists, CB1 cannabinoid receptor antagonists, and GABA receptor agonists. Finally, details of the relapse/reinstatement model will be presented together with potential medications effective in this model. |
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Smissman Award Symposium
9:00 AM-12:30 PM, Monday, August 20, 2007 BCEC -- 210 B/C, Oral
Division of Medicinal Chemistry |