PROF 7 |
| I will talk about recent research efforts in my group on the development of new multifunctional nanomaterials for biological and biomedical applications. Multifunctional inorganic-organic hybrid nanoparticles containing a luminescent core and a paramagnetic coat have been prepared using a general water-in-oil microemulsion-based method, and their utility as multimodal imaging probes has been demonstrated both in vitro and in vivo. A variety of techniques were used to characterize the nanomaterials including SEM, TEM, TGA, and direct current plasma spectroscopy. These nanoparticles exhibit very high r1 and r2 relaxivities per millimolar of Gd3+ (up to 19.7 s-1 and 60.0 s-1, respectively), and extraordinarily high r1 and r2 relaxivities per millimolar of nanoparticles (up to 5 x 105 s-1 and 8 x 105 s-1, respectively) due to the presence of tens of thousands Gd3+ centers per particle. Cellular labeling studies have shown that these nanoparticles exhibit very low cytotoxicity, and have excellent optical and MR contrast enhancing properties. Preliminary in vivo data indicates that these hybrid nanoparticles are excellent contrast agents for imaging choroid plexus carcinoma and inflammatory arthritis in mouse models. |
|
Progress of Chinese-Americans in Academia
1:00 PM-4:45 PM, Sunday, August 19, 2007 Sheraton Boston -- Back Bay Blrm C, Oral
Division of Professional Relations |