POLY 294 |
| Degradable polymers based on Langer's polyanhydrides for drug delivery were designed to integrate the useful attributes of polyanhydrides with bioactive compounds. The near-term goals of this project are multi-fold: to accelerate the recovery/restoration of periodontal architecture by reducing inflammation; to reduce post-operative pain after periodontal surgery; and to create an unfavorable environment for periodontic bacteria. These goals are achieved using biodegradable polymers in which the polymer itself is a controlled-release system: the polymer serves as a temporary barrier that degrades into therapeutically active molecules such as non-steroidal anti-inflammatory drugs (NSAIDs) and concurrently releases admixed antimicrobials. We build upon our progress with salicylate-based polymers to create new NSAID-based polymers (PolyNSAIDs) that simultaneously reduce inflammation, control pain, and eliminate bacteria to not only address periodontal indications, but also deep bone infections, restenosis, inflammatory bowel disease and other related inflammatory diseases. |
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Herman Mark Award in Honor of Robert Langer
1:00 PM-4:55 PM, Monday, August 20, 2007 Westin Boston Waterfront -- Grand Ballroom B, Oral
Division of Polymer Chemistry |