Fluorescence sensing technologies in demanding situations

PROF 5

Lei Zhu, lzhu@chem.fsu.edu, Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390
I started my independent academic career at FSU, after completing my doctoral dissertation in 2003 and postdoctoral research in 2005, at New York University and the University of Texas at Austin, respectively. My graduate training was in the areas of coordination chemistry and nucleic acid chemistry; whereas at UT Austin, I ventured into molecular sensing technologies. Naturally, the focus of my research is the application of organic synthesis to help solve problems in molecular sensing and DNA nanotechnology. For instance, we are interested in how to develop fluorescent probes for dynamically imaging substances with high spatiotemporal variations in live cells. For example, the concentration of intracellular zinc ion may vary from below nanomolar to almost the millimolar range. Currently available highly sensitive zinc probes are unable to cover the over-6-order of magnitude dynamic range. In this presentation, our effort in the development of fluorescent probes targeting zinc with both high sensitivity and large effective dynamic range will be described.