Chemically functionalized viral capsids for light harvesting and diagnostic imaging

PMSE 87

Matthew B. Francis, francis@cchem.berkeley.edu, Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720-1460
Recent progress in nanotechnology has yielded new device components with unprecedented capabilities. However, the small size of these building blocks makes it difficult to position them into functional assemblies using existing patterning techniques. As one solution to this problem, we have converted the protein shells of two viruses into scaffolds that can position nanoscale objects with excellent spatial resolution. In one case, this strategy has been used to synthesize arrays of fluorescent molecules, providing efficient mimics of the light harvesting system present in photosynthetic organisms. In a second research area, well-defined core/shell materials have been prepared for applications in diagnostic imaging. The cornerstone of these efforts has been a series of new synthetic reactions that can modify biomolecules with high site-selectivity and yield. This presentation will focus on the development of these methods and the applications of the new materials that have been built through their use.