Antibacterial effects of sandwich type polyoxometalates against Salmonella typhimurium and Listeria monocytogenes

INOR 694

Anand V Sankarraj, sankaav@auburn.edu1, Syeda K Hussain2, Omar A Oyarzabal2, and Curtis Shannon, shanncg@auburn.edu3. (1) Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, (2) Department of Poultry Science, Auburn University, Auburn, AL 36849, (3) Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312
The antibacterial effects of polyoxometalates are well-known in literature and the Keggin based structures have been very effective against a variety of antibiotic resistant bacteria. In this work, Listeria monocytogenes (gram positive) and Salmonella typhimurium (gram negative), two of the important poultry based pathogens have been tested with novel bimetallic sandwich-type Weakley polyoxometalates {(WZnM2)[ZnW9O34]2}n- , (M = V and Zn). These sandwich type structures have two Keggin units interconnected by a belt of four transition metals. Antimicrobial activities of these POMs have been assessed by the paper disc method and the standard dilution micromethod. The bimetallic sandwich type structures have been compared with V substituted Keggin type (PVW11O40)6- polyoxometalate and a significant bacteriostatic effect has been observed at relatively lower concentrations. Preliminary investigations to determine the synergistic effect of these polyoxometalates with conventional antibiotics will also be reported.
 

Polyoxometalates and Related Clusters in Chemistry and Nanoscience
7:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007