POLY 409 |
| Near-infrared fluorescent (NIRF) dyes are intensively being developed for optical molecular imaging applications. This work focuses on the design, synthesis and application of a nanoparticle-based nanoprobe with a NIRF Cy-7-like dye chemically bonded in polymeric micelles composed of a crosslinked hydrophobic core and a hydrophilic shell with polyethylene glycol (PEG). Pharmacokinetic analysis, ex vivo biodistribution and imaging approaches revealed that nanoparticles with an average diameter of 24 nm exhibited prolonged blood half-life (t1/2, á = 1.25 hr. t1/2, b = 46.18 hr) and moderate uptakes in organs of the mononuclear phagocytic system. Dual modality NIRF optical imaging and gamma scintigraphy of mice bearing subcutaneously inoculated human MDA-MB468 breast tumor clearly revealed accumulation of nanoparticles in the tumors over a period of 5 days after intravenous injection. |
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Synthetic and Biological Macromolecules for Emerging Nanotechnologies
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Polymer Chemistry |