Separations at the micro- and nanoscale

ANYL 360

Stephen C. Jacobson, jacobson@indiana.edu, Michelle L. Kovarik, and Kaimeng Zhou. Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN 47405-7102
Interest in microfluidic-based applications has increased over the past decade primarily because device miniaturization has led to a number of advantages, which include executing fast, efficient, high throughput assays, integrating multiple sample processing steps, and fabricating highly parallel device architectures. As devices continue to shrink and approach the nanometer length scale, issues regarding the feasibility and practicality of these systems must be addressed to determine which lessons from the microscale extrapolate to the nanometer regime. To develop functional nanofluidic systems, we are fabricating and evaluating in-plane (nanochannel) devices where material transport is parallel to the device surface. We are comparing the function and performance of these devices with out-of-plane (nanopore) devices where transport is perpendicular to the device surface. Some aspects of microfluidic transport transfer directly to operation of these nanoscale conduits, while the nanochannels and nanopores offer unique separation opportunities.