COMP 332 |
| Glycolytic enzymes may compartment in cells by binding to cytoskeletal structures. One potentially important step in compartmentation is binding of the cytoskeletal protein F-actin with lactate dehydrogenase (LDH). Tetrameric LDH can have different isoforms of muscle (M) or heart (H) monomers. Brownian dynamics simulations explore the interactions of human and rabbit mixed LDH isoforms with F-actin. The LDH mixed tetrameric isoforms, LDH-M_3 H, LDH-M_2 H_2 , LDH-MH_3 , give distinctive electrostatic potentials and charges. If the positive electrostatic potential region between subunits A/D and subunits B/C, remains intact (such as in M_3 H) the mixed isoforms bind F-actin. |
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Poster Session
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Ballroom Foyer, Poster
Sci-Mix
Division of Computers in Chemistry |