Hybrid gold/polymer nanoparticles for use in bioassays

COLL 391

Tara L Schiller, tara.schiller@gmail.com1, Zul Merican2, Craig J. Hawker3, Idriss Blakey, i.blakey@uq.edu.au2, and Peter M Fredericks1. (1) School of Physical and Chemical Sciences, Queensland University of Technology, Gardens Point, 2 George Street, 4000 Brisbane, Australia, (2) Centre for Magnetic resonance and Australian Institute for Bioengineering and Nanotechnology, University of Queensland, (3) Materials Research Laboratory, University of California at Santa Barbara, Santa Barbara, CA 93106
A method for the self assembly of polymer stabilized gold nanoparticles, where the gold nanoparticles are dispersed in an aqueous medium and the polymer is water insoluble and possesses a dithiocarbamate end group, is presented. A range of techniques were utilized to characterize these novel hybrid materials, which included monitoring the shift of the surface plasmon resonance by UV-Vis spectroscopy, TEM, and FTIR-ATR spectroscopy. The polymer stabilized nanoparticles were also encoded with a range of SERS-active molecules. It was demonstrated that a characteristic SERS signal could be obtained from the polymer hybrids labelled with each SERS encoder. This shows that we can successfully encode the polymer stabilized nanoparticles and decode them with Raman spectroscopy.