Designing cell adhesion 3-D-materials used of self-assembly peptides

POLY 502

Naoki Nishishita and Yoshiaki Hirano, yhirano@chem.oit.ac.jp. Department of Applied Chemistry, Osaka Institute of Technology, 5-16-1 Omiya Asahi-ku Osaka 533-8585, Japan, Osaka, 535-8585, Japan
RGDS cell adhesion peptide have been incorporated into scaffolds to enhance cell adhesion or to allow biospecific interaction. In this work, for improving cell-attachment activity of RGDS peptide for tissue engineering scaffolds, we tried to stabilize the folded conformations of such peptides by designing three types of beta-hairpin peptides having the RGDS sequence at the turn portion. We reported that intramolecular interaction of self-assembly peptides was investigated by quart crystal microbalance (QCM). We confirmed the self-assembly beta-sheet peptide could built up hierarchically organized nanofiber and macrofiber.