INOR 885 |
| Copper (Cu) and iron (Fe) are redox-active metals essential for life. Hydrogen peroxide (H2O2) is also essential for cellular activities and has recently been identified as a second messenger. However, iron, copper and H2O2 are all “double- edged swords” and can be extremely toxic to cells at high concentrations. The chemical nature of this toxicity is largely due to Fenton reaction that generates highly deleterious hydroxyl radicals (HO•, half life ~ 1 ns). We have synthesized a series of novel pro-chelators (e.g. SIH-B) which can sense H2O2 and be converted to active chelators (e.g. SIH) and subsequently sequester iron and copper. This process can effectively attenuate both Fe- and Cu-promoted Fenton reactions (“anti-Fenton reaction”) under physiological relevant conditions. The H2O2-sensed chelating reactivity is promising for developing novel therapeutics. |
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General Inorganic Chemistry
1:30 PM-5:20 PM, Wednesday, August 22, 2007 BCEC -- 212, Oral
Division of Inorganic Chemistry |