CHED 107 |
| Protein primary structure databases are growing exponentially, while tertiary structure databases are lagging. Knowledge of tertiary structure is essential for rational drug design. Homology modeling is widely accepted, suggesting that proteins with at least 30% homology should have similar tertiary structures. In order to study and evaluate this supposition we chose hen egg white (HEW) lysozyme C, a widely studied protein with vast information at all levels of structure as our reference. A blast similarity search was conducted against HEW lysozyme C to obtain proteins that are >25% identical and >30% similar to HEW lysozyme C. The search parameters were set to return one-hundred of the best aligning sequences. Of which only two proteins satisfied the criteria of being functionally different than HEW lysozyme C and expressed in mammals. They are Saca3_human (HSLLP1), and Saca3_mouse (MSLLP1). Here we discuss the methods, constraints, results, and our future plans for this research. |
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General Posters
7:30 PM-9:30 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Chemical Education |