ANYL 344 |
| For drug discovery teams to remain effective, fast, and competitive, a steady stream of high quality bioanalytical data is required to support decision-making. Bioanalysis has traditionally relied on serial LC/MS/MS analysis and is a major bottleneck. This talk details several approaches we have taken to reduce this bottleneck by coupling process design with technological improvements to suit shifting organizational needs and constraints. We have investigated several technologies that have improved assay throughput several fold and evolved to meet organizational changes and needs. These approaches include cassette incubation and cassette analysis, alternating column regeneration, the use of fast gradient separations, and the application of staggered parallel chromatography to the analysis of in vitro samples using off-the shelf solutions has been investigated. The application of these methods to in vitro assays will be presented in the context of the challenges and the efficiencies realized by each methodology, and their organizational fit. |
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Analytical Technology for Drug Discovery
8:30 AM-11:50 AM, Tuesday, August 21, 2007 BCEC -- 105, Oral
Division of Analytical Chemistry |