Dual function silver embedded magnetic nanoprobes and their application for separation, tracking and imaging of cancer cell

ANYL 123

Bong-Hyun Jun, jjcome77@snu.ac.kr1, Misuk Noh, pourlady@snu.ac.kr2, Hyunmi Park, phm81@snu.ac.kr3, Jaeyun Kim, yun3311@snu.ac.kr4, Homan Kang, homkang@gmail.com5, Jong Ho Kim, kjh75@snu.ac.kr1, Min-Su Kim, dumong2@chol.com6, Sang-Myung Lee, onlyrc97@snu.ac.kr1, Yong-Kweon Kim, yongkkim@snu.ac.kr6, Taeghwan Hyeon4, Myung-Haing Cho, mchotox@snu.ac.kr2, Dae Hong Jeong, jeongdh@snu.ac.kr3, and Yoon-Sik Lee, yslee@snu.ac.kr1. (1) School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea, (2) College of Veterinary Medicine, Seoul National University, Seoul, 151-742, South Korea, (3) Department of Chemistry Education, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul, 151-742, South Korea, (4) School of Chemical Engineering, seoul national university, Shinlimdong, seoul, 151-742, South Korea, (5) Seoul National University, Seoul, 151-742, South Korea, (6) School of Electrical Engineering and Computer Science, Seoul National University, Seoul, 151-742, South Korea
Magnetic nanoparticles have been used in the areas of biosciences and biotechnologies for capturing biomolecules, separating target cells and cell organelles, and MRI imaging. Surface-enhanced Raman scattering (SERS) has attracted considerable interest as a sensitive, vibrationally specific probe for chemical and bio-analytical sensing and imaging application. We have recently reported that silver embedded SERS tags (SERS Dot) can be reproducibly fabricated by a simple method.[1] In this work, we demonstrate that the same protocol can be adopted in the fabrication of silver-embedded magnetic silica nanoparticles. They can be taken up by cells, which then, become controllable by an external magnetic field. The silver-embedded magnetic silica nanoparticles are more efficient than SERS substrates for cell imaging and separation. These materials have potential in bio-imaging, drug targeting, bio-sensing, and bio-labeling applications.

[1] Kim et al. Anal. Chem., 2006, 78, 6967-6973.

 

General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007